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AP1B1

GENERAL INFORMATION

Gene name

 AP1B1

Gene description

 Adaptor-related protein complex 1, beta 1 subunit

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA068520
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA068520

GENE INFORMATION

Gene name

 AP1B1 (HGNC Symbol)

Synonyms

 ADTB1, AP105A, BAM22, CLAPB2

Description

 Adaptor-related protein complex 1, beta 1 subunit (HGNC Symbol)

Entrez gene summary

 Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 29327680 - 29423179

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100280 (version 83.38)

Entrez gene

 162

UniProt

 Q10567 (UniProt - Evidence at protein level)

neXtProt

 NX_Q10567

Antibodypedia

 AP1B1 antibodies

PROTEIN BROWSER
AP1B1-001
AP1B1-002
AP1B1-003
AP1B1-004
AP1B1-008
AP1B1-201
AP1B1-202
AP1B1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1B1-001
ENSP00000384194
ENST00000405198
Q10567 [Direct mapping]
AP-1 complex subunit beta-1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
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 949 aa
104.6 kDa 		No 0
AP1B1-002
ENSP00000319361
ENST00000317368
Q10567 [Direct mapping]
AP-1 complex subunit beta-1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
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 919 aa
101.3 kDa 		No 0
AP1B1-003
ENSP00000400022
ENST00000421126
C9J1E7 [Direct mapping]
AP-1 complex subunit beta-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
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 578 aa
65.3 kDa 		No 0
AP1B1-004
ENSP00000386071
ENST00000402502
Q10567 [Direct mapping]
AP-1 complex subunit beta-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 939 aa
103.5 kDa 		No 0
AP1B1-008
ENSP00000392735
ENST00000415756
H7C034 [Direct mapping]
AP-1 complex subunit beta-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 173 aa
19.2 kDa 		No 0
AP1B1-201
ENSP00000350199
ENST00000357586
Q10567 [Direct mapping]
AP-1 complex subunit beta-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 949 aa
104.6 kDa 		No 0
AP1B1-202
ENSP00000387612
ENST00000415447
Q10567 [Direct mapping]
AP-1 complex subunit beta-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 939 aa
103.5 kDa 		No 0
AP1B1-203
ENSP00000400065
ENST00000432560
Q10567 [Direct mapping]
AP-1 complex subunit beta-1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
Show all
 939 aa
103.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.