Expression of MCM5 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MCM5
Gene description	Minichromosome maintenance complex component 5
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression mainly in hematopoietic cells, immune cells, cytotrophoblastic cells in placenta and cells in testis. Also expressed in other cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA000845 , CAB000101
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), renal cancer (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000845	CAB000101

GENE INFORMATION
Gene name	MCM5 (HGNC Symbol)
Synonyms	CDC46
Description	Minichromosome maintenance complex component 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	35400063 - 35425430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100297 (version 83.38)
Entrez gene	4174
UniProt	P33992 (UniProt - Evidence at protein level)
neXtProt	NX_P33992
Antibodypedia	MCM5 antibodies

PROTEIN BROWSER

MCM5-001	MCM5-002	MCM5-008	MCM5-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCM5-001 ENSP00000216122 ENST00000216122	P33992 [Direct mapping] DNA replication licensing factor MCM5 B1AHB0 [Target identity:100%; Query identity:100%] DNA helicase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000784 [nuclear chromosome, telomeric region] GO:0003677 [DNA binding] GO:0003678 [DNA helicase activity] GO:0003682 [chromatin binding] GO:0003688 [DNA replication origin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006270 [DNA replication initiation] GO:0006271 [DNA strand elongation involved in DNA replication] GO:0016020 [membrane] GO:0032508 [DNA duplex unwinding] GO:0042555 [MCM complex] Show all	734 aa 82.3 kDa	No	0
MCM5-002 ENSP00000371441 ENST00000382011	B1AHB1 [Direct mapping] DNA helicase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003678 [DNA helicase activity] GO:0003682 [chromatin binding] GO:0003688 [DNA replication origin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006270 [DNA replication initiation] GO:0032508 [DNA duplex unwinding] GO:0042555 [MCM complex] GO:0051301 [cell division] Show all	691 aa 77.6 kDa	No	0
MCM5-008 ENSP00000393977 ENST00000416905	B1AHA9 [Direct mapping] DNA replication licensing factor MCM5 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003678 [DNA helicase activity] GO:0003682 [chromatin binding] GO:0003688 [DNA replication origin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006270 [DNA replication initiation] GO:0032508 [DNA duplex unwinding] GO:0042555 [MCM complex] Show all	231 aa 25.9 kDa	No	0
MCM5-011 ENSP00000408705 ENST00000444778	B1AHB2 [Direct mapping] DNA replication licensing factor MCM5 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		150 aa 16.8 kDa	No	0