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MCM5

GENERAL INFORMATION

Gene name

 MCM5

Gene description

 Minichromosome maintenance complex component 5

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression mainly in hematopoietic cells, immune cells, cytotrophoblastic cells in placenta and cells in testis. Also expressed in other cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000845 , CAB000101
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MCM5 (HGNC Symbol)

Synonyms

 CDC46

Description

 Minichromosome maintenance complex component 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 35400063 - 35425430

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100297 (version 83.38)

Entrez gene

 4174

UniProt

 P33992 (UniProt - Evidence at protein level)

neXtProt

 NX_P33992

Antibodypedia

 MCM5 antibodies

PROTEIN BROWSER
MCM5-001
MCM5-002
MCM5-008
MCM5-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCM5-001
ENSP00000216122
ENST00000216122
P33992 [Direct mapping]
DNA replication licensing factor MCM5
B1AHB0 [Target identity:100%; Query identity:100%]
DNA helicase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0016020 [membrane]
GO:0032508 [DNA duplex unwinding]
GO:0042555 [MCM complex]
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 734 aa
82.3 kDa 		No 0
MCM5-002
ENSP00000371441
ENST00000382011
B1AHB1 [Direct mapping]
DNA helicase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006270 [DNA replication initiation]
GO:0032508 [DNA duplex unwinding]
GO:0042555 [MCM complex]
GO:0051301 [cell division]
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 691 aa
77.6 kDa 		No 0
MCM5-008
ENSP00000393977
ENST00000416905
B1AHA9 [Direct mapping]
DNA replication licensing factor MCM5
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006270 [DNA replication initiation]
GO:0032508 [DNA duplex unwinding]
GO:0042555 [MCM complex]
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 231 aa
25.9 kDa 		No 0
MCM5-011
ENSP00000408705
ENST00000444778
B1AHB2 [Direct mapping]
DNA replication licensing factor MCM5
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 150 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.