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This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
P01127 [Direct mapping] Platelet-derived growth factor subunit B
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Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001892 [embryonic placenta development] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002548 [monocyte chemotaxis] GO:0002576 [platelet degranulation] GO:0003104 [positive regulation of glomerular filtration] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005788 [endoplasmic reticulum lumen] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007507 [heart development] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009611 [response to wounding] GO:0009986 [cell surface] GO:0010512 [negative regulation of phosphatidylinositol biosynthetic process] GO:0010544 [negative regulation of platelet activation] GO:0010628 [positive regulation of gene expression] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016176 [superoxide-generating NADPH oxidase activator activity] GO:0016323 [basolateral plasma membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032091 [negative regulation of protein binding] GO:0032147 [activation of protein kinase activity] GO:0032148 [activation of protein kinase B activity] GO:0035793 [positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway] GO:0038001 [paracrine signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042056 [chemoattractant activity] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045740 [positive regulation of DNA replication] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048407 [platelet-derived growth factor binding] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918 [positive chemotaxis] GO:0050921 [positive regulation of chemotaxis] GO:0060326 [cell chemotaxis] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070528 [protein kinase C signaling] GO:0071363 [cellular response to growth factor stimulus] GO:0071506 [cellular response to mycophenolic acid] GO:0072126 [positive regulation of glomerular mesangial cell proliferation] GO:0072255 [metanephric glomerular mesangial cell development] GO:0072593 [reactive oxygen species metabolic process] GO:0090280 [positive regulation of calcium ion import] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2000591 [positive regulation of metanephric mesenchymal cell migration]
A9UJP0 [Direct mapping] Platelet-derived growth factor subunit B
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Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A9UJN9 [Direct mapping] Platelet-derived growth factor subunit B
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Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)