Cell atlas - APOL4 - The Human Protein Atlas

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APOL4

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	APOL4
Gene description	Apolipoprotein L, 4
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (HDLM-2, SCLC-21H, K-562, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA055435
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, SCLC-21H, K-562, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055435	RT4	Vesicles
	HPA055435	SH-SY5Y	Vesicles
	HPA055435	U-2 OS	Vesicles	Intensity

GENE INFORMATION
Gene name	APOL4 (HGNC Symbol)
Synonyms	APOLIV
Description	Apolipoprotein L, 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	36189124 - 36204840
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100336 (version 83.38)
Entrez gene	80832
UniProt	Q9BPW4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BPW4
Antibodypedia	APOL4 antibodies

PROTEIN BROWSER

APOL4-001	APOL4-002	APOL4-004	APOL4-006	APOL4-007	APOL4-008	APOL4-009	APOL4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOL4-001 ENSP00000338260 ENST00000352371	Q9BPW4 [Direct mapping] Apolipoprotein L4 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	351 aa 39.2 kDa	No	0
APOL4-002 ENSP00000483497 ENST00000616056	Q9BPW4 [Direct mapping] Apolipoprotein L4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	348 aa 38.7 kDa	No	1
APOL4-004 ENSP00000380445 ENST00000397275	Q9BRG6 [Direct mapping] APOL4 protein; Apolipoprotein L, 4, isoform CRA_c; Apolipoprotein L4 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	107 aa 11.3 kDa	No	0
APOL4-006 ENSP00000409085 ENST00000457630	F5H1P9 [Direct mapping] Apolipoprotein L4 Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	72 aa 8.4 kDa	No	0
APOL4-007 ENSP00000395548 ENST00000419360	B1AHJ0 [Direct mapping] Apolipoprotein L4 Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	65 aa 7.6 kDa	No	0
APOL4-008 ENSP00000393096 ENST00000436763	B1AHJ2 [Direct mapping] Apolipoprotein L4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		25 aa 2.7 kDa	No	0
APOL4-009 ENSP00000333229 ENST00000332987	Q9BPW4 [Direct mapping] Apolipoprotein L4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	348 aa 38.7 kDa	No	1
APOL4-201 ENSP00000331089 ENST00000328429	Q9BRG6 [Direct mapping] APOL4 protein; Apolipoprotein L, 4, isoform CRA_c; Apolipoprotein L4 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	107 aa 11.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.