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APOL4

GENERAL INFORMATION

Gene name

 APOL4

Gene description

 Apolipoprotein L, 4

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, HDLM-2, K-562, SCLC-21H)
HPA (normal tissue):Tissue enhanced (prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA049797
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), renal cancer (unfavourable) and ovarian cancer (favourable).
Urothelial cancer p<0.001
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049797

GENE INFORMATION

Gene name

 APOL4 (HGNC Symbol)

Synonyms

 APOLIV

Description

 Apolipoprotein L, 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 36189124 - 36204840

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100336 (version 83.38)

Entrez gene

 80832

UniProt

 Q9BPW4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9BPW4

Antibodypedia

 APOL4 antibodies

PROTEIN BROWSER
APOL4-001
APOL4-002
APOL4-004
APOL4-006
APOL4-007
APOL4-008
APOL4-009
APOL4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOL4-001
ENSP00000338260
ENST00000352371
Q9BPW4 [Direct mapping]
Apolipoprotein L4
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
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 351 aa
39.2 kDa 		No 0
APOL4-002
ENSP00000483497
ENST00000616056
Q9BPW4 [Direct mapping]
Apolipoprotein L4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
 348 aa
38.7 kDa 		No 1
APOL4-004
ENSP00000380445
ENST00000397275
Q9BRG6 [Direct mapping]
APOL4 protein; Apolipoprotein L, 4, isoform CRA_c; Apolipoprotein L4
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Predicted intracellular proteins
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GO:0005515 [protein binding]
Show all
 107 aa
11.3 kDa 		No 0
APOL4-006
ENSP00000409085
ENST00000457630
F5H1P9 [Direct mapping]
Apolipoprotein L4
Show all
Predicted intracellular proteins
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
 72 aa
8.4 kDa 		No 0
APOL4-007
ENSP00000395548
ENST00000419360
B1AHJ0 [Direct mapping]
Apolipoprotein L4
Show all
Predicted intracellular proteins
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
 65 aa
7.6 kDa 		No 0
APOL4-008
ENSP00000393096
ENST00000436763
B1AHJ2 [Direct mapping]
Apolipoprotein L4
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
 25 aa
2.7 kDa 		No 0
APOL4-009
ENSP00000333229
ENST00000332987
Q9BPW4 [Direct mapping]
Apolipoprotein L4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Show all
GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0042157 [lipoprotein metabolic process]
Show all
 348 aa
38.7 kDa 		No 1
APOL4-201
ENSP00000331089
ENST00000328429
Q9BRG6 [Direct mapping]
APOL4 protein; Apolipoprotein L, 4, isoform CRA_c; Apolipoprotein L4
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Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 107 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.