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Most malignant cells displayed weak to moderate cytoplasmic immunoreactivity. Strong positivity was observed in several malignant melanomas, colorectal, breast and prostate cancers. Several malignant gliomas, testicular, renal, gastric, pancreatic and liver cancers were negative.
Most breast cancers, skin cancers and several cases of malignant melanomas displayed moderate cytoplasmic and occasional membranous positivity. A few cases of malignant gliomas, liver, colorectal and testicular cancers displayed strong cytoplasmic staining. Remaining malignant cells were weakly stained or generally negative.
GENE INFORMATION
Gene name
MYH9 (HGNC Symbol)
Synonyms
DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA
Description
Myosin, heavy chain 9, non-muscle (HGNC Symbol)
Entrez gene summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)