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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MYH9
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MYH9

Gene description

Myosin, heavy chain 9, non-muscle

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues. Distinct expression in renal glomeruli.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA001644 , CAB015386
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001644
CAB015386

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells displayed weak to moderate cytoplasmic immunoreactivity. Strong positivity was observed in several malignant melanomas, colorectal, breast and prostate cancers. Several malignant gliomas, testicular, renal, gastric, pancreatic and liver cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most breast cancers, skin cancers and several cases of malignant melanomas displayed moderate cytoplasmic and occasional membranous positivity. A few cases of malignant gliomas, liver, colorectal and testicular cancers displayed strong cytoplasmic staining. Remaining malignant cells were weakly stained or generally negative.

GENE INFORMATION

Gene name

MYH9 (HGNC Symbol)

Synonyms

DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA

Description

Myosin, heavy chain 9, non-muscle (HGNC Symbol)

Entrez gene summary

This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]

Chromosome

22

Cytoband

q12.3

Chromosome location (bp)

36281281 - 36388018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100345 (version 83.38)

Entrez gene

4627

UniProt

P35579 (UniProt - Evidence at protein level)

neXtProt

NX_P35579

Antibodypedia

MYH9 antibodies

PROTEIN BROWSER

MYH9-001
MYH9-002
MYH9-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH9-001
ENSP00000216181
ENST00000216181
P35579 [Direct mapping]
Myosin-9
A0A024R1N1 [Target identity:100%; Query identity:100%]
Myosin, heavy polypeptide 9, non-muscle, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0000212 [meiotic spindle organization]
GO:0000904 [cell morphogenesis involved in differentiation]
GO:0000910 [cytokinesis]
GO:0001525 [angiogenesis]
GO:0001701 [in utero embryonic development]
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0001768 [establishment of T cell polarity]
GO:0001772 [immunological synapse]
GO:0001931 [uropod]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005826 [actomyosin contractile ring]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0006911 [phagocytosis, engulfment]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007520 [myoblast fusion]
GO:0008180 [COP9 signalosome]
GO:0008305 [integrin complex]
GO:0008360 [regulation of cell shape]
GO:0015031 [protein transport]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016459 [myosin complex]
GO:0016460 [myosin II complex]
GO:0016887 [ATPase activity]
GO:0019904 [protein domain specific binding]
GO:0030048 [actin filament-based movement]
GO:0030220 [platelet formation]
GO:0030224 [monocyte differentiation]
GO:0030863 [cortical cytoskeleton]
GO:0030898 [actin-dependent ATPase activity]
GO:0031032 [actomyosin structure organization]
GO:0031252 [cell leading edge]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031594 [neuromuscular junction]
GO:0032154 [cleavage furrow]
GO:0032796 [uropod organization]
GO:0042641 [actomyosin]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043495 [protein anchor]
GO:0043531 [ADP binding]
GO:0043534 [blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051015 [actin filament binding]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0097513 [myosin II filament]
GO:1903919 [negative regulation of actin filament severing]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
Show all
1960 aa
226.5 kDa
No 0
MYH9-002
ENSP00000384631
ENST00000401701
Q5BKV1 [Direct mapping]
MYH9 protein; Myosin-9
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
218 aa
24.8 kDa
No 0
MYH9-015
ENSP00000414852
ENST00000456729
B1AH99 [Direct mapping]
Myosin-9
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0051015 [actin filament binding]
Show all
103 aa
11.6 kDa
No 0

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The Human Protein Atlas project is funded
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