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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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Antibodies

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MYH9
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MYH9

Gene description

Myosin, heavy chain 9, non-muscle

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues. Distinct expression in renal glomeruli.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA001644 , CAB015386
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

MYH9 (HGNC Symbol)

Synonyms

DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHCA

Description

Myosin, heavy chain 9, non-muscle (HGNC Symbol)

Entrez gene summary

This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]

Chromosome

22

Cytoband

q12.3

Chromosome location (bp)

36281281 - 36388018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100345 (version 83.38)

Entrez gene

4627

UniProt

P35579 (UniProt - Evidence at protein level)

neXtProt

NX_P35579

Antibodypedia

MYH9 antibodies

PROTEIN BROWSER

MYH9-001
MYH9-002
MYH9-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH9-001
ENSP00000216181
ENST00000216181
P35579 [Direct mapping]
Myosin-9
A0A024R1N1 [Target identity:100%; Query identity:100%]
Myosin, heavy polypeptide 9, non-muscle, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0000212 [meiotic spindle organization]
GO:0000904 [cell morphogenesis involved in differentiation]
GO:0000910 [cytokinesis]
GO:0001525 [angiogenesis]
GO:0001701 [in utero embryonic development]
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0001768 [establishment of T cell polarity]
GO:0001772 [immunological synapse]
GO:0001931 [uropod]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005826 [actomyosin contractile ring]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0006911 [phagocytosis, engulfment]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007520 [myoblast fusion]
GO:0008180 [COP9 signalosome]
GO:0008305 [integrin complex]
GO:0008360 [regulation of cell shape]
GO:0015031 [protein transport]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016459 [myosin complex]
GO:0016460 [myosin II complex]
GO:0016887 [ATPase activity]
GO:0019904 [protein domain specific binding]
GO:0030048 [actin filament-based movement]
GO:0030220 [platelet formation]
GO:0030224 [monocyte differentiation]
GO:0030863 [cortical cytoskeleton]
GO:0030898 [actin-dependent ATPase activity]
GO:0031032 [actomyosin structure organization]
GO:0031252 [cell leading edge]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031594 [neuromuscular junction]
GO:0032154 [cleavage furrow]
GO:0032796 [uropod organization]
GO:0042641 [actomyosin]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043495 [protein anchor]
GO:0043531 [ADP binding]
GO:0043534 [blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051015 [actin filament binding]
GO:0051295 [establishment of meiotic spindle localization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0097513 [myosin II filament]
GO:1903919 [negative regulation of actin filament severing]
GO:1903923 [positive regulation of protein processing in phagocytic vesicle]
Show all
1960 aa
226.5 kDa
No 0
MYH9-002
ENSP00000384631
ENST00000401701
Q5BKV1 [Direct mapping]
MYH9 protein; Myosin-9
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
218 aa
24.8 kDa
No 0
MYH9-015
ENSP00000414852
ENST00000456729
B1AH99 [Direct mapping]
Myosin-9
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
GO:0051015 [actin filament binding]
Show all
103 aa
11.6 kDa
No 0

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