Expression of PVALB in cancer - Summary

GENERAL INFORMATION
Gene name	PVALB
Gene description	Parvalbumin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, renal cancer, urothelial cancer)
HPA (cell line):	Cell line enriched (RPMI-8226)
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic and nuclear expression in renal tubules, tonsil, cerebellum and parathyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA048536 , CAB002515
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, renal cancer, urothelial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048536	CAB002515

GENE INFORMATION
Gene name	PVALB (HGNC Symbol)
Synonyms	D22S749
Description	Parvalbumin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	36800684 - 36819479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100362 (version 83.38)
Entrez gene	5816
UniProt	P20472 (UniProt - Evidence at protein level)
neXtProt	NX_P20472
Antibodypedia	PVALB antibodies

PROTEIN BROWSER

PVALB-001	PVALB-002	PVALB-004	PVALB-005	PVALB-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PVALB-001 ENSP00000216200 ENST00000216200	P20472 [Direct mapping] Parvalbumin alpha A0A024R1K9 [Target identity:100%; Query identity:100%] Parvalbumin, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0030424 [axon] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043195 [terminal bouton] GO:0043234 [protein complex] GO:0046982 [protein heterodimerization activity] GO:0051480 [cytosolic calcium ion homeostasis] GO:0070062 [extracellular exosome] Show all	110 aa 12.1 kDa	No	0
PVALB-002 ENSP00000400247 ENST00000417718	P20472 [Direct mapping] Parvalbumin alpha A0A024R1K9 [Target identity:100%; Query identity:100%] Parvalbumin, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0070062 [extracellular exosome] Show all	110 aa 12.1 kDa	No	0
PVALB-004 ENSP00000386089 ENST00000404171	B1AH72 [Direct mapping] Parvalbumin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	78 aa 8.5 kDa	No	0
PVALB-005 ENSP00000384735 ENST00000406910	H0Y3U0 [Direct mapping] Parvalbumin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	106 aa 11.5 kDa	No	0
PVALB-006 ENSP00000406977 ENST00000443735	B8ZZ19 [Direct mapping] Parvalbumin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	101 aa 11.1 kDa	No	0