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PVALB

GENERAL INFORMATION

Gene name

 PVALB

Gene description

 Parvalbumin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Tissue enriched (cerebellum)
FANTOM5:Tissue enhanced (cerebellum, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and nuclear expression in renal tubules, tonsil, cerebellum and parathyroid gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA048536 , CAB002515
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Parathyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, retina)

GENE INFORMATION

Gene name

 PVALB (HGNC Symbol)

Synonyms

 D22S749

Description

 Parvalbumin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 36800684 - 36819479

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100362 (version 83.38)

Entrez gene

 5816

UniProt

 P20472 (UniProt - Evidence at protein level)

neXtProt

 NX_P20472

Antibodypedia

 PVALB antibodies

PROTEIN BROWSER
PVALB-001
PVALB-002
PVALB-004
PVALB-005
PVALB-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PVALB-001
ENSP00000216200
ENST00000216200
P20472 [Direct mapping]
Parvalbumin alpha
A0A024R1K9 [Target identity:100%; Query identity:100%]
Parvalbumin, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0030424 [axon]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0070062 [extracellular exosome]
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 110 aa
12.1 kDa 		No 0
PVALB-002
ENSP00000400247
ENST00000417718
P20472 [Direct mapping]
Parvalbumin alpha
A0A024R1K9 [Target identity:100%; Query identity:100%]
Parvalbumin, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0070062 [extracellular exosome]
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 110 aa
12.1 kDa 		No 0
PVALB-004
ENSP00000386089
ENST00000404171
B1AH72 [Direct mapping]
Parvalbumin alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 78 aa
8.5 kDa 		No 0
PVALB-005
ENSP00000384735
ENST00000406910
H0Y3U0 [Direct mapping]
Parvalbumin alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 106 aa
11.5 kDa 		No 0
PVALB-006
ENSP00000406977
ENST00000443735
B8ZZ19 [Direct mapping]
Parvalbumin alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
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 101 aa
11.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.