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UPK3A

GENERAL INFORMATION

Gene name

 UPK3A

Gene description

 Uroplakin 3A

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (prostate cancer, urothelial cancer)
HPA (cell line):Group enriched (Hep G2, RT4)
HPA (normal tissue):Group enriched (parathyroid gland, prostate, skeletal muscle, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic and membranous expression in urothelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018407 , HPA018415
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (prostate cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA018407
HPA018415

GENE INFORMATION

Gene name

 UPK3A (HGNC Symbol)

Synonyms

 UPK3

Description

 Uroplakin 3A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Chromosome

 22

Cytoband

 q13.31

Chromosome location (bp)

 45284982 - 45295874

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100373 (version 83.38)

Entrez gene

 7380

UniProt

 O75631 (UniProt - Evidence at protein level)

neXtProt

 NX_O75631

Antibodypedia

 UPK3A antibodies

PROTEIN BROWSER
UPK3A-001
UPK3A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UPK3A-001
ENSP00000216211
ENST00000216211
O75631 [Direct mapping]
Uroplakin-3a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
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GO:0000902 [cell morphogenesis]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006833 [water transport]
GO:0015840 [urea transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0030855 [epithelial cell differentiation]
GO:0055075 [potassium ion homeostasis]
GO:0055078 [sodium ion homeostasis]
GO:0060157 [urinary bladder development]
GO:0070062 [extracellular exosome]
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 287 aa
30.7 kDa 		Yes 1
UPK3A-002
ENSP00000379391
ENST00000396082
O75631 [Direct mapping]
Uroplakin-3a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0030855 [epithelial cell differentiation]
GO:0070062 [extracellular exosome]
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 166 aa
17.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.