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UPK3A

GENERAL INFORMATION

Gene name

 UPK3A

Gene description

 Uroplakin 3A

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (parathyroid gland, prostate, skeletal muscle, urinary bladder)
GTEx:Group enriched (prostate, urinary bladder)
FANTOM5:Group enriched (prostate, salivary gland, skeletal muscle, smooth muscle, thyroid gland, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and membranous expression in urothelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018407 , HPA018415
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (parathyroid gland, prostate, skeletal muscle, urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (prostate, urinary bladder)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (prostate, salivary gland, skeletal muscle, smooth muscle, thyroid gland, urinary bladder)

GENE INFORMATION

Gene name

 UPK3A (HGNC Symbol)

Synonyms

 UPK3

Description

 Uroplakin 3A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Chromosome

 22

Cytoband

 q13.31

Chromosome location (bp)

 45284982 - 45295874

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100373 (version 83.38)

Entrez gene

 7380

UniProt

 O75631 (UniProt - Evidence at protein level)

neXtProt

 NX_O75631

Antibodypedia

 UPK3A antibodies

PROTEIN BROWSER
UPK3A-001
UPK3A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UPK3A-001
ENSP00000216211
ENST00000216211
O75631 [Direct mapping]
Uroplakin-3a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0000902 [cell morphogenesis]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006833 [water transport]
GO:0015840 [urea transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0030855 [epithelial cell differentiation]
GO:0055075 [potassium ion homeostasis]
GO:0055078 [sodium ion homeostasis]
GO:0060157 [urinary bladder development]
GO:0070062 [extracellular exosome]
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 287 aa
30.7 kDa 		Yes 1
UPK3A-002
ENSP00000379391
ENST00000396082
O75631 [Direct mapping]
Uroplakin-3a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0030855 [epithelial cell differentiation]
GO:0070062 [extracellular exosome]
Show all
 166 aa
17.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.