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Moderate to strong nuclear immunoreactivity was observed in most malignant cells. Additional cytoplasmic positivity was observed in a majority of cases.
Weak to moderate nuclear positivity was seen in most malignancies.
GENE INFORMATION
Gene name
EP300 (HGNC Symbol)
Synonyms
KAT3B, p300
Description
E1A binding protein p300 (HGNC Symbol)
Entrez gene summary
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000123 [histone acetyltransferase complex] GO:0000278 [mitotic cell cycle] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001666 [response to hypoxia] GO:0001756 [somitogenesis] GO:0002039 [p53 binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004468 [lysine N-acetyltransferase activity, acting on acetyl phosphate as donor] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006473 [protein acetylation] GO:0006475 [internal protein amino acid acetylation] GO:0006915 [apoptotic process] GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response] GO:0007219 [Notch signaling pathway] GO:0007399 [nervous system development] GO:0007507 [heart development] GO:0007519 [skeletal muscle tissue development] GO:0007623 [circadian rhythm] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0016746 [transferase activity, transferring acyl groups] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0018393 [internal peptidyl-lysine acetylation] GO:0030183 [B cell differentiation] GO:0030220 [platelet formation] GO:0030324 [lung development] GO:0031490 [chromatin DNA binding] GO:0032092 [positive regulation of protein binding] GO:0032481 [positive regulation of type I interferon production] GO:0033613 [activating transcription factor binding] GO:0034605 [cellular response to heat] GO:0034644 [cellular response to UV] GO:0035257 [nuclear hormone receptor binding] GO:0035855 [megakaryocyte development] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043627 [response to estrogen] GO:0043923 [positive regulation by host of viral transcription] GO:0043967 [histone H4 acetylation] GO:0043969 [histone H2B acetylation] GO:0045087 [innate immune response] GO:0045444 [fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050681 [androgen receptor binding] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051726 [regulation of cell cycle] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0090043 [regulation of tubulin deacetylation] GO:0097157 [pre-mRNA intronic binding] GO:1900034 [regulation of cellular response to heat]