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POLR3H

GENERAL INFORMATION

Gene name

 POLR3H

Gene description

 Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA046787
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046787

GENE INFORMATION

Gene name

 POLR3H (HGNC Symbol)

Synonyms

 KIAA1665, RPC8

Description

 Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) (HGNC Symbol)

Entrez gene summary

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 41525804 - 41544606

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100413 (version 83.38)

Entrez gene

 171568

UniProt

 Q9Y535 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y535

Antibodypedia

 POLR3H antibodies

PROTEIN BROWSER
POLR3H-001
POLR3H-005
POLR3H-007
POLR3H-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR3H-001
ENSP00000347345
ENST00000355209
Q9Y535 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC8
A0A024R1P3 [Target identity:100%; Query identity:100%]
Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD), isoform CRA_a
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
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 204 aa
22.9 kDa 		No 0
POLR3H-005
ENSP00000385315
ENST00000407461
Q9Y535 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC8
A0A024R1P3 [Target identity:100%; Query identity:100%]
Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD), isoform CRA_a
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 204 aa
22.9 kDa 		No 0
POLR3H-007
ENSP00000337627
ENST00000337566
Q9Y535 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC8
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 175 aa
19.7 kDa 		No 0
POLR3H-201
ENSP00000379761
ENST00000396504
Q9Y535 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC8
A0A024R1P3 [Target identity:100%; Query identity:100%]
Polymerase (RNA) III (DNA directed) polypeptide H (22.9kD), isoform CRA_a
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 204 aa
22.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.