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HDAC10

GENERAL INFORMATION

Gene name

 HDAC10

Gene description

 Histone deacetylase 10

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB045977
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), cervical cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Cervical cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB045977

GENE INFORMATION

Gene name

 HDAC10 (HGNC Symbol)

Synonyms

 DKFZP761B039

Description

 Histone deacetylase 10 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 22

Cytoband

 q13.33

Chromosome location (bp)

 50245183 - 50251405

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100429 (version 83.38)

Entrez gene

 83933

UniProt

 Q969S8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969S8

Antibodypedia

 HDAC10 antibodies

PROTEIN BROWSER
HDAC10-001
HDAC10-005
HDAC10-008
HDAC10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC10-001
ENSP00000216271
ENST00000216271
Q969S8 [Direct mapping]
Histone deacetylase 10
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0007219 [Notch signaling pathway]
GO:0014003 [oligodendrocyte development]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0033558 [protein deacetylase activity]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070932 [histone H3 deacetylation]
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 669 aa
71.4 kDa 		No 1
HDAC10-005
ENSP00000397542
ENST00000448072
C9J8B8 [Direct mapping]
Histone deacetylase 10
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 619 aa
66.2 kDa 		No 1
HDAC10-008
ENSP00000343540
ENST00000349505
Q969S8 [Direct mapping]
Histone deacetylase 10
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006476 [protein deacetylation]
GO:0007219 [Notch signaling pathway]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0033558 [protein deacetylase activity]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070932 [histone H3 deacetylation]
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 649 aa
69.4 kDa 		No 1
HDAC10-201
ENSP00000486864
ENST00000626012
Q08AP5 [Direct mapping]
HDAC10 protein; Histone deacetylase 10
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 96 aa
11.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.