Tissue expression of HDAC10 - Summary - The Human Protein Atlas

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HDAC10

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HDAC10
Gene description	Histone deacetylase 10
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear and cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB045977
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	HDAC10 (HGNC Symbol)
Synonyms	DKFZP761B039
Description	Histone deacetylase 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	50245183 - 50251405
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100429 (version 83.38)
Entrez gene	83933
UniProt	Q969S8 (UniProt - Evidence at protein level)
neXtProt	NX_Q969S8
Antibodypedia	HDAC10 antibodies

PROTEIN BROWSER

HDAC10-001	HDAC10-005	HDAC10-008	HDAC10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HDAC10-001 ENSP00000216271 ENST00000216271	Q969S8 [Direct mapping] Histone deacetylase 10 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006476 [protein deacetylation] GO:0007219 [Notch signaling pathway] GO:0014003 [oligodendrocyte development] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0019899 [enzyme binding] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0033558 [protein deacetylase activity] GO:0042826 [histone deacetylase binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0070932 [histone H3 deacetylation] Show all	669 aa 71.4 kDa	No	1
HDAC10-005 ENSP00000397542 ENST00000448072	C9J8B8 [Direct mapping] Histone deacetylase 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	619 aa 66.2 kDa	No	1
HDAC10-008 ENSP00000343540 ENST00000349505	Q969S8 [Direct mapping] Histone deacetylase 10 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006476 [protein deacetylation] GO:0007219 [Notch signaling pathway] GO:0016568 [chromatin modification] GO:0016575 [histone deacetylation] GO:0019899 [enzyme binding] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0033558 [protein deacetylase activity] GO:0042826 [histone deacetylase binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0070932 [histone H3 deacetylation] Show all	649 aa 69.4 kDa	No	1
HDAC10-201 ENSP00000486864 ENST00000626012	Q08AP5 [Direct mapping] HDAC10 protein; Histone deacetylase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	96 aa 11.2 kDa	No	0

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The Human Protein Atlas

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