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GZMB

GENERAL INFORMATION

Gene name

 GZMB

Gene description

 Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003418 , CAB000376
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA003418
CAB000376

GENE INFORMATION

Gene name

 GZMB (HGNC Symbol)

Synonyms

 CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT

Description

 Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (HGNC Symbol)

Entrez gene summary

 Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 24630954 - 24634267

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100453 (version 83.38)

Entrez gene

 3002

UniProt

 P10144 (UniProt - Evidence at protein level)

neXtProt

 NX_P10144

Antibodypedia

 GZMB antibodies

PROTEIN BROWSER
GZMB-001
GZMB-003
GZMB-005
GZMB-201
GZMB-202
GZMB-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GZMB-001
ENSP00000216341
ENST00000216341
P10144 [Direct mapping]
Granzyme B
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001772 [immunological synapse]
GO:0001913 [T cell mediated cytotoxicity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0007219 [Notch signaling pathway]
GO:0008236 [serine-type peptidase activity]
GO:0008626 [granzyme-mediated apoptotic signaling pathway]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0019835 [cytolysis]
GO:0042267 [natural killer cell mediated cytotoxicity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044194 [cytolytic granule]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
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 247 aa
27.7 kDa 		Yes 0
GZMB-003
ENSP00000387385
ENST00000415355
J3KQ52 [Direct mapping]
Granzyme B; Granzyme B (Granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), isoform CRA_b
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008626 [granzyme-mediated apoptotic signaling pathway]
GO:0016485 [protein processing]
GO:0043231 [intracellular membrane-bounded organelle]
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 235 aa
26.4 kDa 		No 0
GZMB-005
ENSP00000434213
ENST00000526004
E9PRD7 [Direct mapping]
Granzyme B
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0008626 [granzyme-mediated apoptotic signaling pathway]
GO:0016485 [protein processing]
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 90 aa
10.2 kDa 		Yes 0
GZMB-201
ENSP00000371980
ENST00000382540
J3KPK2 [Direct mapping]
Granzyme B
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008626 [granzyme-mediated apoptotic signaling pathway]
GO:0016485 [protein processing]
GO:0043231 [intracellular membrane-bounded organelle]
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 202 aa
22.7 kDa 		Yes 0
GZMB-202
ENSP00000371982
ENST00000382542
J3KPK2 [Direct mapping]
Granzyme B
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0008626 [granzyme-mediated apoptotic signaling pathway]
GO:0016485 [protein processing]
GO:0043231 [intracellular membrane-bounded organelle]
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 202 aa
22.7 kDa 		Yes 0
GZMB-203
ENSP00000479643
ENST00000616551
Q6XGZ2 [Direct mapping]
Granzyme B; Granzyme B splice variant 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0008626 [granzyme-mediated apoptotic signaling pathway]
GO:0016485 [protein processing]
Show all
 152 aa
17 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.