We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
CHGA
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CHGA

Gene description

Chromogranin A

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (pancreatic cancer)
HPA (cell line):Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in neuroendocrine cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 5 antibodies.
HPA017369 , CAB000023 , CAB040544 , CAB055506 , CAB058688
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in breast cancer (favourable), liver cancer (unfavourable), urothelial cancer (unfavourable) and pancreatic cancer (favourable).
Breast cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Carcinoid

STAINING SUMMARY

HPA017369
CAB000023
CAB040544
CAB055506
CAB058688

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Carcinoids and few endometrial cancers along with fraction of cells in few stomach and testicular cancers showed strong cytoplasmic immunoreactivity. Basal cell carcinomas exhibited moderate to strong staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic immunoreactivity was observed in carcinoids and a fraction of cells in several endometrial cancers. Remaining tumour cells were mainly negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant carcinoids, several basal cell carcinomas of skin and a few cases of endometrial cancers displayed strong cytoplasmic positivity. Remaining malignant tissues along with stroma were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Carcinoids and a few cases of endometrial cancers showed strong cytoplasmic staining. Occasional cases of basal cell carcinoma of skin exhibited moderate to strong positivity. Remaining malignant tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of endometrial cancers showed strong cytoplasmic staining along with distinctly stained extracellular material. Basal cell carcinomas and carcinoids displayed strong cytoplasmic staining. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

CHGA

Synonyms

Description

Chromogranin A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

14

Cytoband

q32.12

Chromosome location (bp)

92923080 - 92935293

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100604 (version 83.38)

Entrez gene

1113

UniProt

P10645 (UniProt - Evidence at protein level)

neXtProt

NX_P10645

Antibodypedia

CHGA antibodies

PROTEIN BROWSER

CHGA-001
CHGA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHGA-001
ENSP00000216492
ENST00000216492
P10645 [Direct mapping]
Chromogranin-A Vasostatin-1 Vasostatin-2 EA-92 ES-43 Pancreastatin SS-18 WA-8 WE-14 LF-19 Catestatin AL-11 GV-19 GR-44 ER-37 GE-25 Serpinin-RRG Serpinin p-Glu serpinin precursor
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002551 [mast cell chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006996 [organelle organization]
GO:0008217 [regulation of blood pressure]
GO:0030141 [secretory granule]
GO:0030658 [transport vesicle membrane]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0031640 [killing of cells of other organism]
GO:0032762 [mast cell cytokine production]
GO:0033604 [negative regulation of catecholamine secretion]
GO:0042583 [chromaffin granule]
GO:0042629 [mast cell granule]
GO:0042698 [ovulation cycle]
GO:0043303 [mast cell degranulation]
GO:0045087 [innate immune response]
GO:0045576 [mast cell activation]
GO:0045908 [negative regulation of vasodilation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050832 [defense response to fungus]
GO:1900738 [positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:1901215 [negative regulation of neuron death]
GO:2000707 [positive regulation of dense core granule biogenesis]
Show all
457 aa
50.7 kDa
Yes 0
CHGA-003
ENSP00000334023
ENST00000334654
G5E968 [Direct mapping]
Chromogranin A (Parathyroid secretory protein 1), isoform CRA_b; Chromogranin-A
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030141 [secretory granule]
Show all
306 aa
34.3 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.