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Carcinoids and few endometrial cancers along with fraction of cells in few stomach and testicular cancers showed strong cytoplasmic immunoreactivity. Basal cell carcinomas exhibited moderate to strong staining. Remaining cancer tissues were negative.
Strong cytoplasmic immunoreactivity was observed in carcinoids and a fraction of cells in several endometrial cancers. Remaining tumour cells were mainly negative.
Malignant carcinoids, several basal cell carcinomas of skin and a few cases of endometrial cancers displayed strong cytoplasmic positivity. Remaining malignant tissues along with stroma were negative.
Carcinoids and a few cases of endometrial cancers showed strong cytoplasmic staining. Occasional cases of basal cell carcinoma of skin exhibited moderate to strong positivity. Remaining malignant tissues were negative.
Several cases of endometrial cancers showed strong cytoplasmic staining along with distinctly stained extracellular material. Basal cell carcinomas and carcinoids displayed strong cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
CHGA
Synonyms
Description
Chromogranin A (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]