Majority of cancer tissues showed moderate to strong cytoplasmic positivity. Renal cell carcinomas, thyroid, liver and stomach cancers were weakly stained or negative.
DICER1 (HGNC Symbol)
Dicer, HERNA, K12H4.8-LIKE, KIAA0928, MNG1
Dicer 1, ribonuclease type III (HGNC Symbol)
Entrez gene summary
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]