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DICER1

GENERAL INFORMATION

Gene namei

 DICER1

Gene descriptioni

 Dicer 1, ribonuclease type III

Protein classi

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localizationi

 Intracellular

Number of transcriptsi

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue categoryi
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidencei

 Evidence at protein level

Protein expressioni

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
descriptioni

 Antibody staining mainly consistent with RNA expression data.

Reliability scorei

 Approved based on 2 antibodies.
HPA000694 , CAB068185
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RNA AND PROTEIN EXPRESSION SUMMARYi
RNA expression (TPM)i Protein expression (score)i
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEWi
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEWi
HPA dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATIONi

Gene name

 DICER1 (HGNC Symbol)

Synonyms

 Dicer, HERNA, K12H4.8-LIKE, KIAA0928, MNG1

Description

 Dicer 1, ribonuclease type III (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Chromosome

 14

Cytoband

 q32.13

Chromosome location (bp)

 95086228 - 95158010

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100697 (version 83.38)

Entrez gene

 23405

UniProt

 Q9UPY3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPY3

Antibodypedia

 DICER1 antibodies

PROTEIN BROWSERi
DICER1-001
DICER1-002
DICER1-003
DICER1-004
DICER1-006
DICER1-008
DICER1-014
DICER1-016
DICER1-201

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DICER1-001
ENSP00000343745
ENST00000343455
Q9UPY3 [Direct mapping]
Endoribonuclease Dicer
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0004521 [endoribonuclease activity]
GO:0004525 [ribonuclease III activity]
GO:0004530 [deoxyribonuclease I activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0010626 [negative regulation of Schwann cell proliferation]
GO:0014040 [positive regulation of Schwann cell differentiation]
GO:0016891 [endoribonuclease activity, producing 5'-phosphomonoesters]
GO:0019904 [protein domain specific binding]
GO:0021675 [nerve development]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0031643 [positive regulation of myelination]
GO:0032290 [peripheral nervous system myelin formation]
GO:0033167 [ARC complex]
GO:0033168 [conversion of ds siRNA to ss siRNA involved in RNA interference]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036404 [conversion of ds siRNA to ss siRNA]
GO:0046872 [metal ion binding]
GO:0048812 [neuron projection morphogenesis]
GO:0070578 [RISC-loading complex]
GO:0070883 [pre-miRNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 1922 aa
218.7 kDa 		No 0
DICER1-002
ENSP00000433060
ENST00000531162
Q5D0K5 [Direct mapping]
DICER variant 2; DICER variant 3; Endoribonuclease Dicer
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004530 [deoxyribonuclease I activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006309 [apoptotic DNA fragmentation]
Show all
 70 aa
7.7 kDa 		No 0
DICER1-003
ENSP00000433926
ENST00000529720
Q5D0K5 [Direct mapping]
DICER variant 2; DICER variant 3; Endoribonuclease Dicer
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004530 [deoxyribonuclease I activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006309 [apoptotic DNA fragmentation]
Show all
 70 aa
7.7 kDa 		No 0
DICER1-004
ENSP00000437256
ENST00000526495
Q9UPY3 [Direct mapping]
Endoribonuclease Dicer
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001525 [angiogenesis]
GO:0001942 [hair follicle development]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0004521 [endoribonuclease activity]
GO:0004525 [ribonuclease III activity]
GO:0004530 [deoxyribonuclease I activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006396 [RNA processing]
GO:0008283 [cell proliferation]
GO:0009791 [post-embryonic development]
GO:0010070 [zygote asymmetric cell division]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010626 [negative regulation of Schwann cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010660 [regulation of muscle cell apoptotic process]
GO:0014040 [positive regulation of Schwann cell differentiation]
GO:0014835 [myoblast differentiation involved in skeletal muscle regeneration]
GO:0016891 [endoribonuclease activity, producing 5'-phosphomonoesters]
GO:0019827 [stem cell population maintenance]
GO:0019904 [protein domain specific binding]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021675 [nerve development]
GO:0021889 [olfactory bulb interneuron differentiation]
GO:0021987 [cerebral cortex development]
GO:0030324 [lung development]
GO:0030326 [embryonic limb morphogenesis]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0031069 [hair follicle morphogenesis]
GO:0031641 [regulation of myelination]
GO:0031643 [positive regulation of myelination]
GO:0032290 [peripheral nervous system myelin formation]
GO:0033167 [ARC complex]
GO:0033168 [conversion of ds siRNA to ss siRNA involved in RNA interference]
GO:0035068 [micro-ribonucleoprotein complex]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035198 [miRNA binding]
GO:0035264 [multicellular organism growth]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036404 [conversion of ds siRNA to ss siRNA]
GO:0042487 [regulation of odontogenesis of dentin-containing tooth]
GO:0045069 [regulation of viral genome replication]
GO:0045595 [regulation of cell differentiation]
GO:0045664 [regulation of neuron differentiation]
GO:0046872 [metal ion binding]
GO:0048255 [mRNA stabilization]
GO:0048536 [spleen development]
GO:0048565 [digestive tract development]
GO:0048608 [reproductive structure development]
GO:0048713 [regulation of oligodendrocyte differentiation]
GO:0048730 [epidermis morphogenesis]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048812 [neuron projection morphogenesis]
GO:0048856 [anatomical structure development]
GO:0050767 [regulation of neurogenesis]
GO:0051216 [cartilage development]
GO:0051225 [spindle assembly]
GO:0051252 [regulation of RNA metabolic process]
GO:0051607 [defense response to virus]
GO:0051726 [regulation of cell cycle]
GO:0055013 [cardiac muscle cell development]
GO:0060119 [inner ear receptor cell development]
GO:0060253 [negative regulation of glial cell proliferation]
GO:0060576 [intestinal epithelial cell development]
GO:0061309 [cardiac neural crest cell development involved in outflow tract morphogenesis]
GO:0061548 [ganglion development]
GO:0070173 [regulation of enamel mineralization]
GO:0070578 [RISC-loading complex]
GO:0070883 [pre-miRNA binding]
GO:0071335 [hair follicle cell proliferation]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:2000628 [regulation of miRNA metabolic process]
GO:2000630 [positive regulation of miRNA metabolic process]
Show all
 1922 aa
218.7 kDa 		No 0
DICER1-006
ENSP00000435681
ENST00000527414
Q9UPY3 [Direct mapping]
Endoribonuclease Dicer
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0004521 [endoribonuclease activity]
GO:0004525 [ribonuclease III activity]
GO:0004530 [deoxyribonuclease I activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0010626 [negative regulation of Schwann cell proliferation]
GO:0014040 [positive regulation of Schwann cell differentiation]
GO:0016891 [endoribonuclease activity, producing 5'-phosphomonoesters]
GO:0019904 [protein domain specific binding]
GO:0021675 [nerve development]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0031643 [positive regulation of myelination]
GO:0032290 [peripheral nervous system myelin formation]
GO:0033167 [ARC complex]
GO:0033168 [conversion of ds siRNA to ss siRNA involved in RNA interference]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036404 [conversion of ds siRNA to ss siRNA]
GO:0046872 [metal ion binding]
GO:0048812 [neuron projection morphogenesis]
GO:0070578 [RISC-loading complex]
GO:0070883 [pre-miRNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 1922 aa
218.7 kDa 		No 0
DICER1-008
ENSP00000452556
ENST00000532939
H0YJZ6 [Direct mapping]
Endoribonuclease Dicer
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004525 [ribonuclease III activity]
GO:0004530 [deoxyribonuclease I activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006396 [RNA processing]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 394 aa
45 kDa 		No 0
DICER1-014
ENSP00000451041
ENST00000556045
Q9UPY3 [Direct mapping]
Endoribonuclease Dicer
A0A076VAC5 [Target identity:100%; Query identity:100%]
Dicer1e
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0004521 [endoribonuclease activity]
GO:0004525 [ribonuclease III activity]
GO:0004530 [deoxyribonuclease I activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0010626 [negative regulation of Schwann cell proliferation]
GO:0014040 [positive regulation of Schwann cell differentiation]
GO:0019904 [protein domain specific binding]
GO:0021675 [nerve development]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0031643 [positive regulation of myelination]
GO:0032290 [peripheral nervous system myelin formation]
GO:0033167 [ARC complex]
GO:0033168 [conversion of ds siRNA to ss siRNA involved in RNA interference]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036404 [conversion of ds siRNA to ss siRNA]
GO:0046872 [metal ion binding]
GO:0048812 [neuron projection morphogenesis]
GO:0070578 [RISC-loading complex]
GO:0070883 [pre-miRNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 820 aa
92.7 kDa 		No 0
DICER1-016
ENSP00000444719
ENST00000541352
Q9UPY3 [Direct mapping]
Endoribonuclease Dicer
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0004521 [endoribonuclease activity]
GO:0004525 [ribonuclease III activity]
GO:0004530 [deoxyribonuclease I activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0010626 [negative regulation of Schwann cell proliferation]
GO:0014040 [positive regulation of Schwann cell differentiation]
GO:0016891 [endoribonuclease activity, producing 5'-phosphomonoesters]
GO:0019904 [protein domain specific binding]
GO:0021675 [nerve development]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0031643 [positive regulation of myelination]
GO:0032290 [peripheral nervous system myelin formation]
GO:0033167 [ARC complex]
GO:0033168 [conversion of ds siRNA to ss siRNA involved in RNA interference]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036404 [conversion of ds siRNA to ss siRNA]
GO:0046872 [metal ion binding]
GO:0048812 [neuron projection morphogenesis]
GO:0070578 [RISC-loading complex]
GO:0070883 [pre-miRNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 1829 aa
208.4 kDa 		No 0
DICER1-201
ENSP00000376783
ENST00000393063
Q9UPY3 [Direct mapping]
Endoribonuclease Dicer
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0004521 [endoribonuclease activity]
GO:0004525 [ribonuclease III activity]
GO:0004530 [deoxyribonuclease I activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0010626 [negative regulation of Schwann cell proliferation]
GO:0014040 [positive regulation of Schwann cell differentiation]
GO:0016891 [endoribonuclease activity, producing 5'-phosphomonoesters]
GO:0019904 [protein domain specific binding]
GO:0021675 [nerve development]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0030423 [targeting of mRNA for destruction involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0031643 [positive regulation of myelination]
GO:0032290 [peripheral nervous system myelin formation]
GO:0033167 [ARC complex]
GO:0033168 [conversion of ds siRNA to ss siRNA involved in RNA interference]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036404 [conversion of ds siRNA to ss siRNA]
GO:0046872 [metal ion binding]
GO:0048812 [neuron projection morphogenesis]
GO:0070578 [RISC-loading complex]
GO:0070883 [pre-miRNA binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 1922 aa
218.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.