Cell atlas - ZC3H14 - The Human Protein Atlas

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ZC3H14

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZC3H14
Gene description	Zinc finger CCCH-type containing 14
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (validated)
Mouse	Localized to the Nuclear speckles in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA049798 , HPA053510
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles.

Main location

Nuclear speckles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA049798	A-431	Nuclear speckles
HPA049798	MCF7	Nuclear speckles
HPA049798	U-2 OS	Nuclear speckles
HPA053510	A-431	Nucleoli
HPA053510	A-431	Nuclear speckles
HPA053510	U-2 OS	Nucleoli
HPA053510	U-2 OS	Nuclear speckles
HPA053510	U-251 MG	Nucleoli
HPA053510	U-251 MG	Nuclear speckles

MOUSE CELLS

Main location

Nuclear speckles

Mouse gene

ENSMUSG00000021012 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA053510	NIH 3T3	Nuclear speckles

GENE INFORMATION
Gene name	ZC3H14 (HGNC Symbol)
Synonyms	FLJ11806, NY-REN-37, UKp68
Description	Zinc finger CCCH-type containing 14 (HGNC Symbol)
Entrez gene summary	ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).[supplied by OMIM, Mar 2010]
Chromosome	14
Cytoband	q31.3
Chromosome location (bp)	88562909 - 88627596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100722 (version 83.38)
Entrez gene	79882
UniProt	Q6PJT7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PJT7
Antibodypedia	ZC3H14 antibodies

PROTEIN BROWSER

ZC3H14-001	ZC3H14-002	ZC3H14-005	ZC3H14-006	ZC3H14-007	ZC3H14-008	ZC3H14-009	ZC3H14-011	ZC3H14-012	ZC3H14-013	ZC3H14-015	ZC3H14-018	ZC3H14-019	ZC3H14-020	ZC3H14-021	ZC3H14-022	ZC3H14-025	ZC3H14-027	ZC3H14-028

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZC3H14-001 ENSP00000251038 ENST00000251038	Q6PJT7 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016607 [nuclear speck] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	736 aa 82.9 kDa	No	0
ZC3H14-002 ENSP00000307025 ENST00000302216	Q6PJT7 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016607 [nuclear speck] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	579 aa 65.4 kDa	No	0
ZC3H14-005 ENSP00000450474 ENST00000556945	G3V256 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	605 aa 68.3 kDa	No	0
ZC3H14-006 ENSP00000452370 ENST00000557607	G3V5I6 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	420 aa 47.8 kDa	No	0
ZC3H14-007 ENSP00000452475 ENST00000555755	Q6PJT7 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016607 [nuclear speck] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	730 aa 82.3 kDa	No	0
ZC3H14-008 ENSP00000338002 ENST00000336693	Q6PJT7 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016607 [nuclear speck] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	571 aa 64.5 kDa	No	0
ZC3H14-009 ENSP00000451054 ENST00000556000	H0YJA2 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	651 aa 73.2 kDa	No	0
ZC3H14-011 ENSP00000377150 ENST00000393514	Q6PJT7 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016607 [nuclear speck] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	711 aa 80 kDa	No	0
ZC3H14-012 ENSP00000327176 ENST00000318308	Q6PJT7 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016607 [nuclear speck] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	306 aa 34.9 kDa	No	0
ZC3H14-013 ENSP00000451530 ENST00000555900	G3V411 [Direct mapping] Nuclear protein UKp68, isoform CRA_g; Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	438 aa 49.5 kDa	No	0
ZC3H14-015 ENSP00000384682 ENST00000406216	Q6PJT7 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0008143 [poly(A) binding] GO:0016607 [nuclear speck] GO:0043488 [regulation of mRNA stability] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	282 aa 32.1 kDa	No	0
ZC3H14-018 ENSP00000451638 ENST00000554602	G3V473 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	72 aa 8.1 kDa	No	0
ZC3H14-019 ENSP00000451389 ENST00000556158	G3V3R9 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	210 aa 23.7 kDa	No	0
ZC3H14-020 ENSP00000451489 ENST00000555799	G3V3Y4 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	215 aa 24 kDa	No	0
ZC3H14-021 ENSP00000452210 ENST00000557693	G3V572 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	133 aa 14.8 kDa	No	0
ZC3H14-022 ENSP00000450451 ENST00000555120	G3V240 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	94 aa 10.5 kDa	No	0
ZC3H14-025 ENSP00000451941 ENST00000557737	G3V4R5 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	206 aa 23 kDa	No	0
ZC3H14-027 ENSP00000450823 ENST00000555792	H0YJ51 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:0046872 [metal ion binding] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	151 aa 17.5 kDa	No	0
ZC3H14-028 ENSP00000477763 ENST00000557047	A0A087WTC9 [Direct mapping] Zinc finger CCCH domain-containing protein 14 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008143 [poly(A) binding] GO:0043488 [regulation of mRNA stability] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	148 aa 16.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.