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Most malignant tissues showed moderate nuclear staining with additional cytoplasmic positivity in few cases. A few squamous cell carcinomas of uterine cervix, ovarian and colorectal adenocarcinomas exhibited strong immunoreactivity. Several renal cancers were negative.
Most of cancer tissues displayed weak to moderate nuclear/ nucleolar positivity. Several cases of colorectal cancers along with few cases of breast cancers and a single case each of pancreatic, endometrial and cervical cancer showed additional cytoplasmic membranous staining. Majority cases of liver and renal cancers were negative.
GENE INFORMATION
Gene name
ZC3H14 (HGNC Symbol)
Synonyms
FLJ11806, NY-REN-37, UKp68
Description
Zinc finger CCCH-type containing 14 (HGNC Symbol)
Entrez gene summary
ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).[supplied by OMIM, Mar 2010]