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BDKRB1

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GENERAL INFORMATION

Gene name

 BDKRB1

Gene description

 Bradykinin receptor B1

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-87 MG, U-2197, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, U-2197, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 BDKRB1 (HGNC Symbol)

Synonyms

 B1BKR, BKR1, bradyb1

Description

 Bradykinin receptor B1 (HGNC Symbol)

Entrez gene summary

 Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 14

Cytoband

 q32.2

Chromosome location (bp)

 96255824 - 96268967

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100739 (version 83.38)

Entrez gene

 623

UniProt

 P46663 (UniProt - Evidence at protein level)

neXtProt

 NX_P46663

Antibodypedia

 BDKRB1 antibodies

PROTEIN BROWSER
BDKRB1-001
BDKRB1-002
BDKRB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BDKRB1-001
ENSP00000216629
ENST00000216629
P46663 [Direct mapping]
B1 bradykinin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002687 [positive regulation of leukocyte migration]
GO:0004930 [G-protein coupled receptor activity]
GO:0004947 [bradykinin receptor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0009612 [response to mechanical stimulus]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0019233 [sensory perception of pain]
GO:0030308 [negative regulation of cell growth]
GO:0032496 [response to lipopolysaccharide]
GO:0042277 [peptide binding]
GO:0043005 [neuron projection]
GO:0045776 [negative regulation of blood pressure]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
Show all
 353 aa
40.5 kDa 		No 7
BDKRB1-002
ENSP00000452064
ENST00000553356
G3V4Y2 [Direct mapping]
B1 bradykinin receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004947 [bradykinin receptor activity]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009612 [response to mechanical stimulus]
GO:0016021 [integral component of membrane]
Show all
 284 aa
32.4 kDa 		No 6
BDKRB1-201
ENSP00000479276
ENST00000611804
P46663 [Direct mapping]
B1 bradykinin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009612 [response to mechanical stimulus]
GO:0016021 [integral component of membrane]
Show all
 353 aa
40.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.