Tissue expression of BDKRB1 - Summary - The Human Protein Atlas

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BDKRB1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	BDKRB1
Gene description	Bradykinin receptor B1
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (gallbladder, urinary bladder)
GTEx:	Tissue enhanced (pancreas)
FANTOM5:	Tissue enhanced (appendix, gallbladder)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA002935
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder, urinary bladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pancreas)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, gallbladder)

GENE INFORMATION
Gene name	BDKRB1 (HGNC Symbol)
Synonyms	B1BKR, BKR1, bradyb1
Description	Bradykinin receptor B1 (HGNC Symbol)
Entrez gene summary	Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	96255824 - 96268967
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100739 (version 83.38)
Entrez gene	623
UniProt	P46663 (UniProt - Evidence at protein level)
neXtProt	NX_P46663
Antibodypedia	BDKRB1 antibodies

PROTEIN BROWSER

BDKRB1-001	BDKRB1-002	BDKRB1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BDKRB1-001 ENSP00000216629 ENST00000216629	P46663 [Direct mapping] B1 bradykinin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0002687 [positive regulation of leukocyte migration] GO:0004930 [G-protein coupled receptor activity] GO:0004947 [bradykinin receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0019233 [sensory perception of pain] GO:0030308 [negative regulation of cell growth] GO:0032496 [response to lipopolysaccharide] GO:0042277 [peptide binding] GO:0043005 [neuron projection] GO:0045776 [negative regulation of blood pressure] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	353 aa 40.5 kDa	No	7
BDKRB1-002 ENSP00000452064 ENST00000553356	G3V4Y2 [Direct mapping] B1 bradykinin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004947 [bradykinin receptor activity] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] Show all	284 aa 32.4 kDa	No	6
BDKRB1-201 ENSP00000479276 ENST00000611804	P46663 [Direct mapping] B1 bradykinin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] Show all	353 aa 40.5 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.