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RPS6KA5

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GENERAL INFORMATION

Gene name

 RPS6KA5

Gene description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 5

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA001780 , CAB025458
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001780 RH-30 Nucleoplasm
HPA001780 U-2 OS No staining    
HPA001780 U-251 MG Nucleoplasm
CAB025458 A-431 Nucleoplasm
CAB025458 U-2 OS Nucleoplasm
CAB025458 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 RPS6KA5 (HGNC Symbol)

Synonyms

 MSK1, RLPK

Description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q32.11

Chromosome location (bp)

 90847862 - 91060636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100784 (version 83.38)

Entrez gene

 9252

UniProt

 O75582 (UniProt - Evidence at protein level)

neXtProt

 NX_O75582

Antibodypedia

 RPS6KA5 antibodies

PROTEIN BROWSER
RPS6KA5-001
RPS6KA5-003
RPS6KA5-004
RPS6KA5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS6KA5-001
ENSP00000479667
ENST00000614987
O75582 [Direct mapping]
Ribosomal protein S6 kinase alpha-5
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001818 [negative regulation of cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016572 [histone phosphorylation]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0043990 [histone H2A-S1 phosphorylation]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
Show all
 802 aa
89.9 kDa 		No 0
RPS6KA5-003
ENSP00000402787
ENST00000418736
O75582 [Direct mapping]
Ribosomal protein S6 kinase alpha-5
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001818 [negative regulation of cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016572 [histone phosphorylation]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0043990 [histone H2A-S1 phosphorylation]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
Show all
 549 aa
61.8 kDa 		No 0
RPS6KA5-004
ENSP00000442803
ENST00000536315
O75582 [Direct mapping]
Ribosomal protein S6 kinase alpha-5
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001818 [negative regulation of cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016572 [histone phosphorylation]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0043990 [histone H2A-S1 phosphorylation]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
Show all
 723 aa
81.8 kDa 		No 0
RPS6KA5-201
ENSP00000261991
ENST00000261991
A0A0A0MQV2 [Direct mapping]
Ribosomal protein S6 kinase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0043987 [histone H3-S10 phosphorylation]
Show all
 807 aa
90.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.