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RPS6KA5

GENERAL INFORMATION

Gene name

 RPS6KA5

Gene description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 5

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA001274 , CAB025458
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001274
CAB025458

GENE INFORMATION

Gene name

 RPS6KA5 (HGNC Symbol)

Synonyms

 MSK1, RLPK

Description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q32.11

Chromosome location (bp)

 90847862 - 91060636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100784 (version 83.38)

Entrez gene

 9252

UniProt

 O75582 (UniProt - Evidence at protein level)

neXtProt

 NX_O75582

Antibodypedia

 RPS6KA5 antibodies

PROTEIN BROWSER
RPS6KA5-001
RPS6KA5-003
RPS6KA5-004
RPS6KA5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS6KA5-001
ENSP00000479667
ENST00000614987
O75582 [Direct mapping]
Ribosomal protein S6 kinase alpha-5
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001818 [negative regulation of cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016572 [histone phosphorylation]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0043990 [histone H2A-S1 phosphorylation]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
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 802 aa
89.9 kDa 		No 0
RPS6KA5-003
ENSP00000402787
ENST00000418736
O75582 [Direct mapping]
Ribosomal protein S6 kinase alpha-5
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001818 [negative regulation of cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016572 [histone phosphorylation]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0043990 [histone H2A-S1 phosphorylation]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
Show all
 549 aa
61.8 kDa 		No 0
RPS6KA5-004
ENSP00000442803
ENST00000536315
O75582 [Direct mapping]
Ribosomal protein S6 kinase alpha-5
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001818 [negative regulation of cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016572 [histone phosphorylation]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033129 [positive regulation of histone phosphorylation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0043990 [histone H2A-S1 phosphorylation]
GO:0045087 [innate immune response]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
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 723 aa
81.8 kDa 		No 0
RPS6KA5-201
ENSP00000261991
ENST00000261991
A0A0A0MQV2 [Direct mapping]
Ribosomal protein S6 kinase
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0035556 [intracellular signal transduction]
GO:0043987 [histone H3-S10 phosphorylation]
Show all
 807 aa
90.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.