Expression of BRMS1L in cancer - Summary

GENERAL INFORMATION
Gene name	BRMS1L
Gene description	Breast cancer metastasis-suppressor 1-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues with additional high, membranous expression in glomeruli.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA046623
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), renal cancer (favourable), liver cancer (unfavourable) and breast cancer (unfavourable).
Urothelial cancer p<0.001 Renal cancer p<0.001 Liver cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA046623

GENE INFORMATION
Gene name	BRMS1L (HGNC Symbol)
Synonyms	BRMS1, FLJ39177, MGC11296
Description	Breast cancer metastasis-suppressor 1-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q13.2
Chromosome location (bp)	35826318 - 35932325
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100916 (version 83.38)
Entrez gene	84312
UniProt	Q5PSV4 (UniProt - Evidence at protein level)
neXtProt	NX_Q5PSV4
Antibodypedia	BRMS1L antibodies

PROTEIN BROWSER

BRMS1L-001	BRMS1L-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRMS1L-001 ENSP00000216807 ENST00000216807	Q5PSV4 [Direct mapping] Breast cancer metastasis-suppressor 1-like protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0016575 [histone deacetylation] GO:0040008 [regulation of growth] GO:0042826 [histone deacetylase binding] GO:0070822 [Sin3-type complex] Show all	323 aa 37.6 kDa	No	0
BRMS1L-006 ENSP00000446826 ENST00000551774	H0YHD0 [Direct mapping] Breast cancer metastasis-suppressor 1-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0004407 [histone deacetylase activity] GO:0016575 [histone deacetylation] GO:0042826 [histone deacetylase binding] GO:0070822 [Sin3-type complex] Show all	215 aa 25 kDa	No	0