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SGK2

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GENERAL INFORMATION

Gene name

 SGK2

Gene description

 Serum/glucocorticoid regulated kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Group enriched (RPTEC TERT1, A549, Hep G2, CAPAN-2, EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA008859
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPTEC TERT1, A549, Hep G2, CAPAN-2, EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA008859 A549 Nucleoplasm
HPA008859 RT4 Nucleoplasm

GENE INFORMATION

Gene name

 SGK2

Synonyms

Description

 Serum/glucocorticoid regulated kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 43558968 - 43588237

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101049 (version 83.38)

Entrez gene

 10110

UniProt

 Q9HBY8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBY8

Antibodypedia

 SGK2 antibodies

PROTEIN BROWSER
SGK2-001
SGK2-002
SGK2-005
SGK2-007
SGK2-009
SGK2-011
SGK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGK2-001
ENSP00000362184
ENST00000373092
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 367 aa
41.2 kDa 		No 0
SGK2-002
ENSP00000340608
ENST00000341458
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 427 aa
47.6 kDa 		No 0
SGK2-005
ENSP00000362192
ENST00000373100
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 367 aa
41.2 kDa 		No 0
SGK2-007
ENSP00000396222
ENST00000412111
Q5H8Y5 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 198 aa
22.1 kDa 		No 0
SGK2-009
ENSP00000481432
ENST00000617268
A0A0G2JNI2 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 10 aa
0.9 kDa 		No 0
SGK2-011
ENSP00000412214
ENST00000426287
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 393 aa
44 kDa 		No 0
SGK2-201
ENSP00000392795
ENST00000423407
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 367 aa
41.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.