Fields »
ABOUT
HELP
BLOG
SGK2

GENERAL INFORMATION

Gene name

 SGK2

Gene description

 Serum/glucocorticoid regulated kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, endometrial cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer, urothelial cancer)
HPA (cell line):Group enriched (A549, CAPAN-2, EFO-21, Hep G2, RPTEC TERT1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA011387
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, endometrial cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011387

GENE INFORMATION

Gene name

 SGK2

Synonyms

Description

 Serum/glucocorticoid regulated kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 43558968 - 43588237

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101049 (version 83.38)

Entrez gene

 10110

UniProt

 Q9HBY8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBY8

Antibodypedia

 SGK2 antibodies

PROTEIN BROWSER
SGK2-001
SGK2-002
SGK2-005
SGK2-007
SGK2-009
SGK2-011
SGK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGK2-001
ENSP00000362184
ENST00000373092
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 367 aa
41.2 kDa 		No 0
SGK2-002
ENSP00000340608
ENST00000341458
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 427 aa
47.6 kDa 		No 0
SGK2-005
ENSP00000362192
ENST00000373100
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 367 aa
41.2 kDa 		No 0
SGK2-007
ENSP00000396222
ENST00000412111
Q5H8Y5 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 198 aa
22.1 kDa 		No 0
SGK2-009
ENSP00000481432
ENST00000617268
A0A0G2JNI2 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 10 aa
0.9 kDa 		No 0
SGK2-011
ENSP00000412214
ENST00000426287
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 393 aa
44 kDa 		No 0
SGK2-201
ENSP00000392795
ENST00000423407
Q9HBY8 [Direct mapping]
Serine/threonine-protein kinase Sgk2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006979 [response to oxidative stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0055085 [transmembrane transport]
Show all
 367 aa
41.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.