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The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000287 [magnesium ion binding] GO:0000902 [cell morphogenesis] GO:0001569 [patterning of blood vessels] GO:0001841 [neural tube formation] GO:0001934 [positive regulation of protein phosphorylation] GO:0003157 [endocardium development] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007417 [central nervous system development] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0018105 [peptidyl-serine phosphorylation] GO:0023014 [signal transduction by protein phosphorylation] GO:0030216 [keratinocyte differentiation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032092 [positive regulation of protein binding] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035329 [hippo signaling] GO:0035556 [intracellular signal transduction] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043234 [protein complex] GO:0043539 [protein serine/threonine kinase activator activity] GO:0045600 [positive regulation of fat cell differentiation] GO:0046621 [negative regulation of organ growth] GO:0046777 [protein autophosphorylation] GO:0046983 [protein dimerization activity] GO:0050821 [protein stabilization] GO:0060215 [primitive hemopoiesis] GO:0060706 [cell differentiation involved in embryonic placenta development] GO:0060800 [regulation of cell differentiation involved in embryonic placenta development] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097284 [hepatocyte apoptotic process] GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]