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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

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Method

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Searches

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Cell line

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Cancer

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Detectable

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Detectable

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STK4
  • TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

STK4

Gene description

Serine/threonine kinase 4

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, high expression in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA015270 , CAB004038
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

STK4 (HGNC Symbol)

Synonyms

KRS2, MST1, YSK3

Description

Serine/threonine kinase 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q13.12

Chromosome location (bp)

44966474 - 45079959

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101109 (version 83.38)

Entrez gene

6789

UniProt

Q13043 (UniProt - Evidence at protein level)

neXtProt

NX_Q13043

Antibodypedia

STK4 antibodies

PROTEIN BROWSER

STK4-003
STK4-005
STK4-006
STK4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STK4-003
ENSP00000361892
ENST00000372806
Q13043 [Direct mapping]
Serine/threonine-protein kinase 4 Serine/threonine-protein kinase 4 37kDa subunit Serine/threonine-protein kinase 4 18kDa subunit
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0000902 [cell morphogenesis]
GO:0001569 [patterning of blood vessels]
GO:0001841 [neural tube formation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003157 [endocardium development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007417 [central nervous system development]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030216 [keratinocyte differentiation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032092 [positive regulation of protein binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035329 [hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0046621 [negative regulation of organ growth]
GO:0046777 [protein autophosphorylation]
GO:0046983 [protein dimerization activity]
GO:0050821 [protein stabilization]
GO:0060215 [primitive hemopoiesis]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0060800 [regulation of cell differentiation involved in embryonic placenta development]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097284 [hepatocyte apoptotic process]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
487 aa
55.6 kDa
No 0
STK4-005
ENSP00000479564
ENST00000474717
A0A087WVN8 [Direct mapping]
Serine/threonine-protein kinase 4
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
Show all
155 aa
17.4 kDa
No 0
STK4-006
ENSP00000361887
ENST00000372801
Q13043 [Direct mapping]
Serine/threonine-protein kinase 4 Serine/threonine-protein kinase 4 37kDa subunit Serine/threonine-protein kinase 4 18kDa subunit
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0000902 [cell morphogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032092 [positive regulation of protein binding]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035329 [hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0046777 [protein autophosphorylation]
GO:0046983 [protein dimerization activity]
GO:0050821 [protein stabilization]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
462 aa
52.3 kDa
No 0
STK4-201
ENSP00000443514
ENST00000499879
F5H5B4 [Direct mapping]
Serine/threonine-protein kinase 4
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
Show all
432 aa
49.5 kDa
No 0

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