Cell atlas - ADNP - The Human Protein Atlas

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ADNP

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ADNP
Gene description	Activity-dependent neuroprotector homeobox
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006371
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006371	A-431	Nucleoplasm
	HPA006371	U-2 OS	Nucleoplasm
	HPA006371	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	ADNP (HGNC Symbol)
Synonyms	ADNP1, KIAA0784
Description	Activity-dependent neuroprotector homeobox (HGNC Symbol)
Entrez gene summary	Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	50888919 - 50931240
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101126 (version 83.38)
Entrez gene	23394
UniProt	Q9H2P0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2P0
Antibodypedia	ADNP antibodies

PROTEIN BROWSER

ADNP-001	ADNP-002	ADNP-003	ADNP-005	ADNP-006	ADNP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADNP-001 ENSP00000360662 ENST00000371602	Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1102 aa 123.6 kDa	No	0
ADNP-002 ENSP00000379346 ENST00000396029	Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007614 [short-term memory] GO:0009743 [response to carbohydrate] GO:0010035 [response to inorganic substance] GO:0010629 [negative regulation of gene expression] GO:0010835 [regulation of protein ADP-ribosylation] GO:0010976 [positive regulation of neuron projection development] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030828 [positive regulation of cGMP biosynthetic process] GO:0031668 [cellular response to extracellular stimulus] GO:0032091 [negative regulation of protein binding] GO:0032147 [activation of protein kinase activity] GO:0033484 [nitric oxide homeostasis] GO:0042277 [peptide binding] GO:0043025 [neuronal cell body] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044849 [estrous cycle] GO:0045773 [positive regulation of axon extension] GO:0046872 [metal ion binding] GO:0048487 [beta-tubulin binding] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050805 [negative regulation of synaptic transmission] GO:0051965 [positive regulation of synapse assembly] Show all	1102 aa 123.6 kDa	No	0
ADNP-003 ENSP00000342905 ENST00000349014	Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1102 aa 123.6 kDa	No	0
ADNP-005 ENSP00000436181 ENST00000534467	E9PQK8 [Direct mapping] Activity-dependent neuroprotector homeobox protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		173 aa 20.1 kDa	No	0
ADNP-006 ENSP00000379349 ENST00000396032	Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1102 aa 123.6 kDa	No	0
ADNP-201 ENSP00000483881 ENST00000621696	Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1102 aa 123.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.