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ADNP

GENERAL INFORMATION

Gene name

 ADNP

Gene description

 Activity-dependent neuroprotector homeobox

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA006371
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006371

GENE INFORMATION

Gene name

 ADNP (HGNC Symbol)

Synonyms

 ADNP1, KIAA0784

Description

 Activity-dependent neuroprotector homeobox (HGNC Symbol)

Entrez gene summary

 Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.13

Chromosome location (bp)

 50888919 - 50931240

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101126 (version 83.38)

Entrez gene

 23394

UniProt

 Q9H2P0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2P0

Antibodypedia

 ADNP antibodies

PROTEIN BROWSER
ADNP-001
ADNP-002
ADNP-003
ADNP-005
ADNP-006
ADNP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADNP-001
ENSP00000360662
ENST00000371602
Q9H2P0 [Direct mapping]
Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 1102 aa
123.6 kDa 		No 0
ADNP-002
ENSP00000379346
ENST00000396029
Q9H2P0 [Direct mapping]
Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007614 [short-term memory]
GO:0009743 [response to carbohydrate]
GO:0010035 [response to inorganic substance]
GO:0010629 [negative regulation of gene expression]
GO:0010835 [regulation of protein ADP-ribosylation]
GO:0010976 [positive regulation of neuron projection development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030828 [positive regulation of cGMP biosynthetic process]
GO:0031668 [cellular response to extracellular stimulus]
GO:0032091 [negative regulation of protein binding]
GO:0032147 [activation of protein kinase activity]
GO:0033484 [nitric oxide homeostasis]
GO:0042277 [peptide binding]
GO:0043025 [neuronal cell body]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044849 [estrous cycle]
GO:0045773 [positive regulation of axon extension]
GO:0046872 [metal ion binding]
GO:0048487 [beta-tubulin binding]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050805 [negative regulation of synaptic transmission]
GO:0051965 [positive regulation of synapse assembly]
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 1102 aa
123.6 kDa 		No 0
ADNP-003
ENSP00000342905
ENST00000349014
Q9H2P0 [Direct mapping]
Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 1102 aa
123.6 kDa 		No 0
ADNP-005
ENSP00000436181
ENST00000534467
E9PQK8 [Direct mapping]
Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 173 aa
20.1 kDa 		No 0
ADNP-006
ENSP00000379349
ENST00000396032
Q9H2P0 [Direct mapping]
Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 1102 aa
123.6 kDa 		No 0
ADNP-201
ENSP00000483881
ENST00000621696
Q9H2P0 [Direct mapping]
Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 1102 aa
123.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.