Tissue expression of SLC52A3 - Summary - The Human Protein Atlas

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SLC52A3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC52A3
Gene description	Solute carrier family 52 (riboflavin transporter), member 3
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types, most abundant in testis.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049391
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

N/A

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Small intestine

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION
Gene name	SLC52A3 (HGNC Symbol)
Synonyms	bA371L19.1, C20orf54, hRFT2, RFVT3
Description	Solute carrier family 52 (riboflavin transporter), member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a riboflavin transporter protein that is strongly expressed in the intestine and likely plays a role in intestinal absorption of riboflavin. The protein is predicted to have eleven transmembrane domains and a cell surface localization signal in the C-terminus. Mutations at this locus have been associated with Brown-Vialetto-Van Laere syndrome and Fazio-Londe disease. [provided by RefSeq, Mar 2012]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	760080 - 776015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101276 (version 83.38)
Entrez gene	113278
UniProt	Q9NQ40 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQ40
Antibodypedia	SLC52A3 antibodies

PROTEIN BROWSER

SLC52A3-001	SLC52A3-004	SLC52A3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC52A3-001 ENSP00000217254 ENST00000217254	Q9NQ40 [Direct mapping] Solute carrier family 52, riboflavin transporter, member 3 K0A6P4 [Target identity:100%; Query identity:100%] Chromosome 20 open reading frame 54, isoform CRA_c; Solute carrier family 52 member 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0007605 [sensory perception of sound] GO:0016324 [apical plasma membrane] GO:0032217 [riboflavin transporter activity] GO:0032218 [riboflavin transport] GO:0044281 [small molecule metabolic process] Show all	469 aa 50.8 kDa	Yes	>9
SLC52A3-004 ENSP00000371370 ENST00000381944	Q9NQ40 [Direct mapping] Solute carrier family 52, riboflavin transporter, member 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0007605 [sensory perception of sound] GO:0016324 [apical plasma membrane] GO:0032217 [riboflavin transporter activity] GO:0032218 [riboflavin transport] GO:0044281 [small molecule metabolic process] Show all	415 aa 45 kDa	Yes	8
SLC52A3-201 ENSP00000488723 ENST00000632431	Q9NQ40 [Direct mapping] Solute carrier family 52, riboflavin transporter, member 3 K0A6P4 [Target identity:100%; Query identity:100%] Chromosome 20 open reading frame 54, isoform CRA_c; Solute carrier family 52 member 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0007605 [sensory perception of sound] GO:0016324 [apical plasma membrane] GO:0032217 [riboflavin transporter activity] GO:0032218 [riboflavin transport] GO:0034605 [cellular response to heat] GO:0044281 [small molecule metabolic process] Show all	469 aa 50.8 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.