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SNPH

GENERAL INFORMATION

Gene name

 SNPH

Gene description

 Syntaphilin

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in several tissues, including processes in brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA049393
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049393

GENE INFORMATION

Gene name

 SNPH (HGNC Symbol)

Synonyms

 bA314N13.5

Description

 Syntaphilin (HGNC Symbol)

Entrez gene summary

 Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 1266316 - 1309328

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101298 (version 83.38)

Entrez gene

 9751

UniProt

 O15079 (UniProt - Evidence at protein level)

neXtProt

 NX_O15079

Antibodypedia

 SNPH antibodies

PROTEIN BROWSER
SNPH-001
SNPH-002
SNPH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNPH-001
ENSP00000371291
ENST00000381867
O15079 [Direct mapping]
Syntaphilin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005881 [cytoplasmic microtubule]
GO:0007269 [neurotransmitter secretion]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
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 538 aa
58 kDa 		No 1
SNPH-002
ENSP00000371297
ENST00000381873
O15079 [Direct mapping]
Syntaphilin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0007269 [neurotransmitter secretion]
GO:0007420 [brain development]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0031966 [mitochondrial membrane]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045202 [synapse]
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 494 aa
53.5 kDa 		No 1
SNPH-201
ENSP00000479696
ENST00000614659
O15079 [Direct mapping]
Syntaphilin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005881 [cytoplasmic microtubule]
GO:0007269 [neurotransmitter secretion]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
Show all
 538 aa
58 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.