Cell atlas - SNPH - The Human Protein Atlas

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SNPH

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Mitochondria

Human cell
	Microtubules
	Mitochondria

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GENERAL INFORMATION
Gene name	SNPH
Gene description	Syntaphilin
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the cytokinetic bridge.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (uncertain)
Additional location	In addition localized to the Cytokinetic bridge (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA049393
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the cytokinetic bridge.

Main location

Mitochondria (uncertain)

Additional location

Cytokinetic bridge (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049393	A549	Cytokinetic bridge	Intensity	Intensity
	HPA049393	A549	Mitochondria
	HPA049393	PC-3	Mitochondria
	HPA049393	U-2 OS	Mitochondria

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	SNPH (HGNC Symbol)
Synonyms	bA314N13.5
Description	Syntaphilin (HGNC Symbol)
Entrez gene summary	Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	1266316 - 1309328
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101298 (version 83.38)
Entrez gene	9751
UniProt	O15079 (UniProt - Evidence at protein level)
neXtProt	NX_O15079
Antibodypedia	SNPH antibodies

PROTEIN BROWSER

SNPH-001	SNPH-002	SNPH-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNPH-001 ENSP00000371291 ENST00000381867	O15079 [Direct mapping] Syntaphilin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005881 [cytoplasmic microtubule] GO:0007269 [neurotransmitter secretion] GO:0016021 [integral component of membrane] GO:0016081 [synaptic vesicle docking] GO:0017075 [syntaxin-1 binding] GO:0030054 [cell junction] GO:0043005 [neuron projection] GO:0045202 [synapse] Show all	538 aa 58 kDa	No	1
SNPH-002 ENSP00000371297 ENST00000381873	O15079 [Direct mapping] Syntaphilin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0007269 [neurotransmitter secretion] GO:0007420 [brain development] GO:0016021 [integral component of membrane] GO:0016081 [synaptic vesicle docking] GO:0017075 [syntaxin-1 binding] GO:0030054 [cell junction] GO:0030182 [neuron differentiation] GO:0031966 [mitochondrial membrane] GO:0042734 [presynaptic membrane] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0045202 [synapse] Show all	494 aa 53.5 kDa	No	1
SNPH-201 ENSP00000479696 ENST00000614659	O15079 [Direct mapping] Syntaphilin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005881 [cytoplasmic microtubule] GO:0007269 [neurotransmitter secretion] GO:0016021 [integral component of membrane] GO:0016081 [synaptic vesicle docking] GO:0017075 [syntaxin-1 binding] GO:0030054 [cell junction] GO:0043005 [neuron projection] GO:0045202 [synapse] Show all	538 aa 58 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.