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CDK5RAP1

GENERAL INFORMATION

Gene name

 CDK5RAP1

Gene description

 CDK5 regulatory subunit associated protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CDK5RAP1 (HGNC Symbol)

Synonyms

 C20orf34, C42, CGI-05, HSPC167

Description

 CDK5 regulatory subunit associated protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 33358839 - 33401561

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101391 (version 83.38)

Entrez gene

 51654

UniProt

 Q96SZ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96SZ6

Antibodypedia

 CDK5RAP1 antibodies

PROTEIN BROWSER
CDK5RAP1-007
CDK5RAP1-010
CDK5RAP1-011
CDK5RAP1-012
CDK5RAP1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDK5RAP1-007
ENSP00000409474
ENST00000427097
H0Y721 [Direct mapping]
CDK5 regulatory subunit-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0009451 [RNA modification]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 256 aa
28.5 kDa 		No 0
CDK5RAP1-010
ENSP00000217372
ENST00000346416
Q96SZ6 [Direct mapping]
CDK5 regulatory subunit-associated protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0003824 [catalytic activity]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0009451 [RNA modification]
GO:0016740 [transferase activity]
GO:0019887 [protein kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0032403 [protein complex binding]
GO:0043412 [macromolecule modification]
GO:0045664 [regulation of neuron differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 587 aa
66.1 kDa 		No 0
CDK5RAP1-011
ENSP00000350558
ENST00000357886
Q96SZ6 [Direct mapping]
CDK5 regulatory subunit-associated protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0009451 [RNA modification]
GO:0016740 [transferase activity]
GO:0019887 [protein kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0043412 [macromolecule modification]
GO:0045664 [regulation of neuron differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 601 aa
67.7 kDa 		No 0
CDK5RAP1-012
ENSP00000341840
ENST00000339269
Q96SZ6 [Direct mapping]
CDK5 regulatory subunit-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0009451 [RNA modification]
GO:0019887 [protein kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0045664 [regulation of neuron differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 510 aa
57.4 kDa 		No 0
CDK5RAP1-013
ENSP00000476857
ENST00000473997
Q96SZ6 [Direct mapping]
CDK5 regulatory subunit-associated protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0007420 [brain development]
GO:0009451 [RNA modification]
GO:0016740 [transferase activity]
GO:0019887 [protein kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0043412 [macromolecule modification]
GO:0045664 [regulation of neuron differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 497 aa
56.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.