Tissue expression of BPI - Summary - The Human Protein Atlas

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BPI

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	BPI
Gene description	Bactericidal/permeability-increasing protein
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (bone marrow)
GTEx:	Group enriched (spleen, testis)
FANTOM5:	Group enriched (heart muscle, testis)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in a fraction of hematopoietic cells and in subsets of leukocytes.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA061284
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (heart muscle, testis)

GENE INFORMATION
Gene name	BPI (HGNC Symbol)
Synonyms	BPIFD1
Description	Bactericidal/permeability-increasing protein (HGNC Symbol)
Entrez gene summary	This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	38260149 - 38337505
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101425 (version 83.38)
Entrez gene	671
UniProt	P17213 (UniProt - Evidence at protein level)
neXtProt	NX_P17213
Antibodypedia	BPI antibodies

PROTEIN BROWSER

BPI-001	BPI-002	BPI-006	BPI-007	BPI-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BPI-001 ENSP00000409833 ENST00000417318	H0Y738 [Direct mapping] Bactericidal permeability-increasing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008289 [lipid binding] Show all	286 aa 31.9 kDa	No	0
BPI-002 ENSP00000262865 ENST00000262865	P17213 [Direct mapping] Bactericidal permeability-increasing protein Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001530 [lipopolysaccharide binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0008289 [lipid binding] GO:0032715 [negative regulation of interleukin-6 production] GO:0032717 [negative regulation of interleukin-8 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0042742 [defense response to bacterium] GO:0043031 [negative regulation of macrophage activation] GO:0070062 [extracellular exosome] Show all	487 aa 53.9 kDa	Yes	0
BPI-006 ENSP00000393126 ENST00000418004	A2A2A2 [Direct mapping] Bactericidal permeability-increasing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	123 aa 13.2 kDa	No	1
BPI-007 ENSP00000487406 ENST00000479646	A0A0D9SGE1 [Direct mapping] Bactericidal permeability-increasing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.1 kDa	No	0
BPI-008 ENSP00000391511 ENST00000451435	A2A2A1 [Direct mapping] Bactericidal permeability-increasing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.