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Most cancers displayed moderate cytoplasmic and/or nuclear immunoreactivity. Colorectal, cervical, prostate cancers along with several breast, ovarian and endometrial cancers were negative.
Most cancer tissues showed weak to moderate cytoplasmic and/or nuclear immunoreactivity with additional membranous positivity in a few cases.
GENE INFORMATION
Gene name
AHCY (HGNC Symbol)
Synonyms
SAHH
Description
Adenosylhomocysteinase (HGNC Symbol)
Entrez gene summary
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)