Expression of SYNDIG1 in cancer - Summary

GENERAL INFORMATION
Gene name	SYNDIG1
Gene description	Synapse differentiation inducing 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (Karpas-707, RH-30, RPMI-8226, SCLC-21H, U-87 MG)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA data suggests expression in several tissues, most abundant in cerebral cortex and heart muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA059267
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA059267

GENE INFORMATION
Gene name	SYNDIG1 (HGNC Symbol)
Synonyms	C20orf39, FLJ14220, IFITMD5, SynDIG1, TMEM90B
Description	Synapse differentiation inducing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	24469199 - 24666616
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101463 (version 83.38)
Entrez gene	79953
UniProt	Q9H7V2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H7V2
Antibodypedia	SYNDIG1 antibodies

PROTEIN BROWSER

SYNDIG1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYNDIG1-001 ENSP00000366058 ENST00000376862	Q9H7V2 [Direct mapping] Synapse differentiation-inducing gene protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006886 [intracellular protein transport] GO:0009607 [response to biotic stimulus] GO:0014069 [postsynaptic density] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0031901 [early endosome membrane] GO:0035254 [glutamate receptor binding] GO:0042803 [protein homodimerization activity] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0044297 [cell body] GO:0045211 [postsynaptic membrane] GO:0051965 [positive regulation of synapse assembly] GO:0060076 [excitatory synapse] GO:0097091 [synaptic vesicle clustering] Show all	258 aa 28.6 kDa	No	2