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SYNDIG1

GENERAL INFORMATION

Gene name

 SYNDIG1

Gene description

 Synapse differentiation inducing 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:Tissue enhanced (brain, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 RNA data suggests expression in several tissues, most abundant in cerebral cortex and heart muscle.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA059267
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 SYNDIG1 (HGNC Symbol)

Synonyms

 C20orf39, FLJ14220, IFITMD5, SynDIG1, TMEM90B

Description

 Synapse differentiation inducing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. [provided by RefSeq, Jul 2013]

Chromosome

 20

Cytoband

 p11.21

Chromosome location (bp)

 24469199 - 24666616

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101463 (version 83.38)

Entrez gene

 79953

UniProt

 Q9H7V2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H7V2

Antibodypedia

 SYNDIG1 antibodies

PROTEIN BROWSER
SYNDIG1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYNDIG1-001
ENSP00000366058
ENST00000376862
Q9H7V2 [Direct mapping]
Synapse differentiation-inducing gene protein 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0009607 [response to biotic stimulus]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031901 [early endosome membrane]
GO:0035254 [glutamate receptor binding]
GO:0042803 [protein homodimerization activity]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0044297 [cell body]
GO:0045211 [postsynaptic membrane]
GO:0051965 [positive regulation of synapse assembly]
GO:0060076 [excitatory synapse]
GO:0097091 [synaptic vesicle clustering]
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 258 aa
28.6 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.