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MYOM1

GENERAL INFORMATION

Gene name

 MYOM1

Gene description

 Myomesin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in myocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA014305 , HPA049193
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014305
HPA049193

GENE INFORMATION

Gene name

 MYOM1

Synonyms

Description

 Myomesin 1 (HGNC Symbol)

Entrez gene summary

 The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 p11.31

Chromosome location (bp)

 3066807 - 3220108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101605 (version 83.38)

Entrez gene

 8736

UniProt

 P52179 (UniProt - Evidence at protein level)

neXtProt

 NX_P52179

Antibodypedia

 MYOM1 antibodies

PROTEIN BROWSER
MYOM1-001
MYOM1-003
MYOM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYOM1-001
ENSP00000348821
ENST00000356443
P52179 [Direct mapping]
Myomesin-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005863 [striated muscle myosin thick filament]
GO:0006936 [muscle contraction]
GO:0008307 [structural constituent of muscle]
GO:0030017 [sarcomere]
GO:0031430 [M band]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 1685 aa
187.6 kDa 		No 0
MYOM1-003
ENSP00000261606
ENST00000261606
P52179 [Direct mapping]
Myomesin-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005863 [striated muscle myosin thick filament]
GO:0008307 [structural constituent of muscle]
GO:0031430 [M band]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 1589 aa
177.7 kDa 		No 0
MYOM1-201
ENSP00000383413
ENST00000400569
A8MX12 [Direct mapping]
Myomesin-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 1452 aa
162.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.