Cell atlas - ANKRD12 - The Human Protein Atlas

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ANKRD12

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ANKRD12
Gene description	Ankyrin repeat domain 12
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA040705
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040705	A-431	Nucleoplasm
	HPA040705	A-431	Cytosol
	HPA040705	U-2 OS	Nucleoplasm
	HPA040705	U-2 OS	Cytosol
	HPA040705	U-251 MG	Nucleoplasm
	HPA040705	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ANKRD12 (HGNC Symbol)
Synonyms	FLJ20053, GAC-1, KIAA0874
Description	Ankyrin repeat domain 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Chromosome	18
Cytoband	p11.22
Chromosome location (bp)	9136228 - 9285985
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101745 (version 83.38)
Entrez gene	23253
UniProt	Q6UB98 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UB98
Antibodypedia	ANKRD12 antibodies

PROTEIN BROWSER

ANKRD12-001	ANKRD12-002	ANKRD12-004	ANKRD12-005	ANKRD12-006	ANKRD12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD12-001 ENSP00000262126 ENST00000262126	Q6UB98 [Direct mapping] Ankyrin repeat domain-containing protein 12 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	2062 aa 235.7 kDa	No	0
ANKRD12-002 ENSP00000382897 ENST00000400020	Q6UB98 [Direct mapping] Ankyrin repeat domain-containing protein 12 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	2039 aa 233 kDa	No	0
ANKRD12-004 ENSP00000441510 ENST00000546007	F5GYX2 [Direct mapping] Ankyrin repeat domain-containing protein 12 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	310 aa 34.4 kDa	No	0
ANKRD12-005 ENSP00000462312 ENST00000577992	J3KS53 [Direct mapping] Ankyrin repeat domain-containing protein 12 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		12 aa 1.3 kDa	No	0
ANKRD12-006 ENSP00000464422 ENST00000585234	J3QRX3 [Direct mapping] Ankyrin repeat domain-containing protein 12 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		45 aa 5.1 kDa	No	0
ANKRD12-201 ENSP00000372932 ENST00000383440	A0A0A0MRY7 [Direct mapping] Ankyrin repeat domain-containing protein 12 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all		438 aa 50.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.