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CSTF2

GENERAL INFORMATION

Gene name

 CSTF2

Gene description

 Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000427 , CAB004680
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CSTF2

Synonyms

Description

 Cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q22.1

Chromosome location (bp)

 100820359 - 100840932

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101811 (version 83.38)

Entrez gene

 1478

UniProt

 P33240 (UniProt - Evidence at protein level)

neXtProt

 NX_P33240

Antibodypedia

 CSTF2 antibodies

PROTEIN BROWSER
CSTF2-001
CSTF2-004
CSTF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSTF2-001
ENSP00000362063
ENST00000372972
P33240 [Direct mapping]
Cleavage stimulation factor subunit 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006378 [mRNA polyadenylation]
GO:0006379 [mRNA cleavage]
GO:0008033 [tRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0071920 [cleavage body]
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 577 aa
61 kDa 		No 0
CSTF2-004
ENSP00000415705
ENST00000413437
A0A0A0MT56 [Direct mapping]
Cleavage stimulation factor subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 225 aa
24.7 kDa 		No 0
CSTF2-201
ENSP00000387996
ENST00000415585
E7EWR4 [Direct mapping]
Cleavage stimulation factor subunit 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0031124 [mRNA 3'-end processing]
GO:1990090 [cellular response to nerve growth factor stimulus]
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 597 aa
62.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.