Expression of GPR143 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GPR143

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR143
Gene description	G protein-coupled receptor 143
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic staining mainly in melanocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA003648
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003648

GENE INFORMATION
Gene name	GPR143 (HGNC Symbol)
Synonyms	OA1
Description	G protein-coupled receptor 143 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	9725346 - 9786297
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101850 (version 83.38)
Entrez gene	4935
UniProt	P51810 (UniProt - Evidence at protein level)
neXtProt	NX_P51810
Antibodypedia	GPR143 antibodies

PROTEIN BROWSER

GPR143-001	GPR143-002	GPR143-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR143-001 ENSP00000417161 ENST00000467482	P51810 [Direct mapping] G-protein coupled receptor 143 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006726 [eye pigment biosynthetic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007601 [visual perception] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0032400 [melanosome localization] GO:0032402 [melanosome transport] GO:0032438 [melanosome organization] GO:0033162 [melanosome membrane] GO:0035240 [dopamine binding] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0035643 [L-DOPA receptor activity] GO:0042470 [melanosome] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050848 [regulation of calcium-mediated signaling] GO:0072544 [L-DOPA binding] GO:0072545 [tyrosine binding] GO:1902908 [regulation of melanosome transport] GO:1903056 [regulation of melanosome organization] Show all	404 aa 43.9 kDa	No	7
GPR143-002 ENSP00000390546 ENST00000447366	H7BZN6 [Direct mapping] G-protein-coupled receptor 143 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	267 aa 30.1 kDa	No	5
GPR143-003 ENSP00000406138 ENST00000431126	C9J9N1 [Direct mapping] G-protein-coupled receptor 143 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	171 aa 19.4 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.