Fields »
ABOUT
HELP
BLOG
GPR143

GENERAL INFORMATION

Gene name

 GPR143

Gene description

 G protein-coupled receptor 143

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic staining mainly in melanocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003648
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 GPR143 (HGNC Symbol)

Synonyms

 OA1

Description

 G protein-coupled receptor 143 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 9725346 - 9786297

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101850 (version 83.38)

Entrez gene

 4935

UniProt

 P51810 (UniProt - Evidence at protein level)

neXtProt

 NX_P51810

Antibodypedia

 GPR143 antibodies

PROTEIN BROWSER
GPR143-001
GPR143-002
GPR143-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPR143-001
ENSP00000417161
ENST00000467482
P51810 [Direct mapping]
G-protein coupled receptor 143
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006726 [eye pigment biosynthetic process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007601 [visual perception]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0032400 [melanosome localization]
GO:0032402 [melanosome transport]
GO:0032438 [melanosome organization]
GO:0033162 [melanosome membrane]
GO:0035240 [dopamine binding]
GO:0035584 [calcium-mediated signaling using intracellular calcium source]
GO:0035643 [L-DOPA receptor activity]
GO:0042470 [melanosome]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0072544 [L-DOPA binding]
GO:0072545 [tyrosine binding]
GO:1902908 [regulation of melanosome transport]
GO:1903056 [regulation of melanosome organization]
Show all
 404 aa
43.9 kDa 		No 7
GPR143-002
ENSP00000390546
ENST00000447366
H7BZN6 [Direct mapping]
G-protein-coupled receptor 143
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 267 aa
30.1 kDa 		No 5
GPR143-003
ENSP00000406138
ENST00000431126
C9J9N1 [Direct mapping]
G-protein-coupled receptor 143
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 171 aa
19.4 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.