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Most cancer tissues were weakly stained or negative. Few cases of testis, liver, melanomas and gliomas and gynaecological cancers sowed moderate cytoplasmic positivity.
Several cases of renal cancers and a single case of papillary adenocarcinoma of thyroid showed moderate cytoplasmic and occasional membranous staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
CHRDL1 (HGNC Symbol)
Synonyms
CHL, MGC1, NRLN1
Description
Chordin-like 1 (HGNC Symbol)
Entrez gene summary
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]