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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BMX
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BMX

Gene description

BMX non-receptor tyrosine kinase

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HUVEC TERT2)
HPA (normal tissue):Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in epididymis.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

Supported based on 2 antibodies.
HPA001048 , CAB032495
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA001048
CAB032495

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most skin cancers along with a few cases of cervical, breast, urothelial, head and neck cancers showed moderate to strong cytoplasmic staining. Remaining malignant cells were mainly negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic positivity was observed in a single case of head and neck cancer. Subsets of blood vessels in tumor stroma of several cancer tissues showed moderate to strong cytoplasmic positivity. Tumor cells were weakly stained or negative.

GENE INFORMATION

Gene name

BMX (HGNC Symbol)

Synonyms

ETK, PSCTK3

Description

BMX non-receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

15464246 - 15556529

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102010 (version 83.38)

Entrez gene

660

UniProt

P51813 (UniProt - Evidence at protein level)

neXtProt

NX_P51813

Antibodypedia

BMX antibodies

PROTEIN BROWSER

BMX-001
BMX-005
BMX-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMX-001
ENSP00000340082
ENST00000342014
P51813 [Direct mapping]
Cytoplasmic tyrosine-protein kinase BMX
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0012501 [programmed cell death]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
Show all
675 aa
78 kDa
No 0
BMX-005
ENSP00000350224
ENST00000357607
P51813 [Direct mapping]
Cytoplasmic tyrosine-protein kinase BMX
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0012501 [programmed cell death]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
Show all
675 aa
78 kDa
No 0
BMX-006
ENSP00000308774
ENST00000348343
P51813 [Direct mapping]
Cytoplasmic tyrosine-protein kinase BMX
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007498 [mesoderm development]
GO:0012501 [programmed cell death]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032587 [ruffle membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
Show all
675 aa
78 kDa
No 0

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