Cell atlas - NAA10 - The Human Protein Atlas

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NAA10

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	NAA10
Gene description	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Additional location	In addition localized to the Nucleoli (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA030711
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoli.

Main location

Cytosol (validated)

Additional location

Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030711	A-431	Cytosol
	HPA030711	U-2 OS	Cytosol
	HPA030711	U-251 MG	Nucleoli
	HPA030711	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NAA10 (HGNC Symbol)
Synonyms	ARD1, ARD1A, DXS707, TE2
Description	N(alpha)-acetyltransferase 10, NatA catalytic subunit (HGNC Symbol)
Entrez gene summary	N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153929242 - 153935223
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102030 (version 83.38)
Entrez gene	8260
UniProt	P41227 (UniProt - Evidence at protein level)
neXtProt	NX_P41227
Antibodypedia	NAA10 antibodies

PROTEIN BROWSER

NAA10-001	NAA10-002	NAA10-012	NAA10-013	NAA10-014	NAA10-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAA10-001 ENSP00000417763 ENST00000464845	P41227 [Direct mapping] N-alpha-acetyltransferase 10 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004596 [peptide alpha-N-acetyltransferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006323 [DNA packaging] GO:0006474 [N-terminal protein amino acid acetylation] GO:0006475 [internal protein amino acid acetylation] GO:0008080 [N-acetyltransferase activity] GO:0016020 [membrane] GO:0016407 [acetyltransferase activity] GO:0017198 [N-terminal peptidyl-serine acetylation] GO:0018002 [N-terminal peptidyl-glutamic acid acetylation] GO:0022626 [cytosolic ribosome] GO:0031415 [NatA complex] GO:0043022 [ribosome binding] GO:1990189 [peptide-serine-N-acetyltransferase activity] GO:1990190 [peptide-glutamate-N-acetyltransferase activity] Show all	235 aa 26.5 kDa	No	0
NAA10-002 ENSP00000359026 ENST00000370009	P41227 [Direct mapping] N-alpha-acetyltransferase 10 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004596 [peptide alpha-N-acetyltransferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006323 [DNA packaging] GO:0006474 [N-terminal protein amino acid acetylation] GO:0006475 [internal protein amino acid acetylation] GO:0008080 [N-acetyltransferase activity] GO:0016020 [membrane] GO:0016407 [acetyltransferase activity] GO:0017198 [N-terminal peptidyl-serine acetylation] GO:0018002 [N-terminal peptidyl-glutamic acid acetylation] GO:0022626 [cytosolic ribosome] GO:0031415 [NatA complex] GO:0043022 [ribosome binding] GO:1990189 [peptide-serine-N-acetyltransferase activity] GO:1990190 [peptide-glutamate-N-acetyltransferase activity] Show all	220 aa 24.8 kDa	No	0
NAA10-012 ENSP00000359032 ENST00000370015	F8W808 [Direct mapping] N-alpha-acetyltransferase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008080 [N-acetyltransferase activity] GO:0017198 [N-terminal peptidyl-serine acetylation] GO:0018002 [N-terminal peptidyl-glutamic acid acetylation] GO:0022626 [cytosolic ribosome] GO:1990189 [peptide-serine-N-acetyltransferase activity] GO:1990190 [peptide-glutamate-N-acetyltransferase activity] Show all	169 aa 19.4 kDa	No	0
NAA10-013 ENSP00000413668 ENST00000432089	C9JW55 [Direct mapping] N-alpha-acetyltransferase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008080 [N-acetyltransferase activity] GO:0017198 [N-terminal peptidyl-serine acetylation] GO:0018002 [N-terminal peptidyl-glutamic acid acetylation] GO:0022626 [cytosolic ribosome] GO:1990189 [peptide-serine-N-acetyltransferase activity] GO:1990190 [peptide-glutamate-N-acetyltransferase activity] Show all	146 aa 17 kDa	No	0
NAA10-014 ENSP00000359028 ENST00000370011	C9JN83 [Direct mapping] N-alpha-acetyltransferase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008080 [N-acetyltransferase activity] GO:0017198 [N-terminal peptidyl-serine acetylation] GO:0018002 [N-terminal peptidyl-glutamic acid acetylation] GO:0022626 [cytosolic ribosome] GO:1990189 [peptide-serine-N-acetyltransferase activity] GO:1990190 [peptide-glutamate-N-acetyltransferase activity] Show all	142 aa 16.7 kDa	No	0
NAA10-015 ENSP00000377315 ENST00000393712	A8MWP7 [Direct mapping] N-alpha-acetyltransferase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008080 [N-acetyltransferase activity] GO:0017198 [N-terminal peptidyl-serine acetylation] GO:0018002 [N-terminal peptidyl-glutamic acid acetylation] GO:0022626 [cytosolic ribosome] GO:1990189 [peptide-serine-N-acetyltransferase activity] GO:1990190 [peptide-glutamate-N-acetyltransferase activity] Show all	184 aa 21.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.