Fields »
ABOUT
HELP
BLOG
NAA10

GENERAL INFORMATION

Gene name

 NAA10

Gene description

 N(alpha)-acetyltransferase 10, NatA catalytic subunit

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissue types, most abundant in glandular epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA030711 , CAB006269
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030711
CAB006269

GENE INFORMATION

Gene name

 NAA10 (HGNC Symbol)

Synonyms

 ARD1, ARD1A, DXS707, TE2

Description

 N(alpha)-acetyltransferase 10, NatA catalytic subunit (HGNC Symbol)

Entrez gene summary

 N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153929242 - 153935223

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102030 (version 83.38)

Entrez gene

 8260

UniProt

 P41227 (UniProt - Evidence at protein level)

neXtProt

 NX_P41227

Antibodypedia

 NAA10 antibodies

PROTEIN BROWSER
NAA10-001
NAA10-002
NAA10-012
NAA10-013
NAA10-014
NAA10-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NAA10-001
ENSP00000417763
ENST00000464845
P41227 [Direct mapping]
N-alpha-acetyltransferase 10
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004596 [peptide alpha-N-acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006323 [DNA packaging]
GO:0006474 [N-terminal protein amino acid acetylation]
GO:0006475 [internal protein amino acid acetylation]
GO:0008080 [N-acetyltransferase activity]
GO:0016020 [membrane]
GO:0016407 [acetyltransferase activity]
GO:0017198 [N-terminal peptidyl-serine acetylation]
GO:0018002 [N-terminal peptidyl-glutamic acid acetylation]
GO:0022626 [cytosolic ribosome]
GO:0031415 [NatA complex]
GO:0043022 [ribosome binding]
GO:1990189 [peptide-serine-N-acetyltransferase activity]
GO:1990190 [peptide-glutamate-N-acetyltransferase activity]
Show all
 235 aa
26.5 kDa 		No 0
NAA10-002
ENSP00000359026
ENST00000370009
P41227 [Direct mapping]
N-alpha-acetyltransferase 10
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004596 [peptide alpha-N-acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006323 [DNA packaging]
GO:0006474 [N-terminal protein amino acid acetylation]
GO:0006475 [internal protein amino acid acetylation]
GO:0008080 [N-acetyltransferase activity]
GO:0016020 [membrane]
GO:0016407 [acetyltransferase activity]
GO:0017198 [N-terminal peptidyl-serine acetylation]
GO:0018002 [N-terminal peptidyl-glutamic acid acetylation]
GO:0022626 [cytosolic ribosome]
GO:0031415 [NatA complex]
GO:0043022 [ribosome binding]
GO:1990189 [peptide-serine-N-acetyltransferase activity]
GO:1990190 [peptide-glutamate-N-acetyltransferase activity]
Show all
 220 aa
24.8 kDa 		No 0
NAA10-012
ENSP00000359032
ENST00000370015
F8W808 [Direct mapping]
N-alpha-acetyltransferase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008080 [N-acetyltransferase activity]
GO:0017198 [N-terminal peptidyl-serine acetylation]
GO:0018002 [N-terminal peptidyl-glutamic acid acetylation]
GO:0022626 [cytosolic ribosome]
GO:1990189 [peptide-serine-N-acetyltransferase activity]
GO:1990190 [peptide-glutamate-N-acetyltransferase activity]
Show all
 169 aa
19.4 kDa 		No 0
NAA10-013
ENSP00000413668
ENST00000432089
C9JW55 [Direct mapping]
N-alpha-acetyltransferase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008080 [N-acetyltransferase activity]
GO:0017198 [N-terminal peptidyl-serine acetylation]
GO:0018002 [N-terminal peptidyl-glutamic acid acetylation]
GO:0022626 [cytosolic ribosome]
GO:1990189 [peptide-serine-N-acetyltransferase activity]
GO:1990190 [peptide-glutamate-N-acetyltransferase activity]
Show all
 146 aa
17 kDa 		No 0
NAA10-014
ENSP00000359028
ENST00000370011
C9JN83 [Direct mapping]
N-alpha-acetyltransferase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008080 [N-acetyltransferase activity]
GO:0017198 [N-terminal peptidyl-serine acetylation]
GO:0018002 [N-terminal peptidyl-glutamic acid acetylation]
GO:0022626 [cytosolic ribosome]
GO:1990189 [peptide-serine-N-acetyltransferase activity]
GO:1990190 [peptide-glutamate-N-acetyltransferase activity]
Show all
 142 aa
16.7 kDa 		No 0
NAA10-015
ENSP00000377315
ENST00000393712
A8MWP7 [Direct mapping]
N-alpha-acetyltransferase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008080 [N-acetyltransferase activity]
GO:0017198 [N-terminal peptidyl-serine acetylation]
GO:0018002 [N-terminal peptidyl-glutamic acid acetylation]
GO:0022626 [cytosolic ribosome]
GO:1990189 [peptide-serine-N-acetyltransferase activity]
GO:1990190 [peptide-glutamate-N-acetyltransferase activity]
Show all
 184 aa
21.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.