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PQBP1

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GENERAL INFORMATION

Gene name

 PQBP1

Gene description

 Polyglutamine binding protein 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA001880
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles.

Main location

 Nuclear speckles (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001880 A-431 Nuclear speckles
HPA001880 U-2 OS Nuclear speckles
HPA001880 U-251 MG Nuclear speckles
Cytosol

siRNA VALIDATION

Antibody

 HPA001880

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

 70%

p-value

 < 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA001880 siRNA 1 U-2 OS
HPA001880 scrambled U-2 OS

GENE INFORMATION

Gene name

 PQBP1 (HGNC Symbol)

Synonyms

 MRX2, MRX55, MRXS8, RENS1, SHS

Description

 Polyglutamine binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48897912 - 48903143

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102103 (version 83.38)

Entrez gene

 10084

UniProt

 O60828 (UniProt - Evidence at protein level)

neXtProt

 NX_O60828

Antibodypedia

 PQBP1 antibodies

PROTEIN BROWSER
PQBP1-001
PQBP1-002
PQBP1-007
PQBP1-011
PQBP1-201
PQBP1-202
PQBP1-203
PQBP1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PQBP1-001
ENSP00000391759
ENST00000447146
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 265 aa
30.5 kDa 		No 0
PQBP1-002
ENSP00000247140
ENST00000247140
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 170 aa
18.8 kDa 		No 0
PQBP1-007
ENSP00000393013
ENST00000456306
H7C053 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 150 aa
16.5 kDa 		No 0
PQBP1-011
ENSP00000414861
ENST00000443648
C9JQA1 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0034063 [stress granule assembly]
Show all
 213 aa
24.9 kDa 		No 0
PQBP1-201
ENSP00000218224
ENST00000218224
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008022 [protein C-terminus binding]
GO:0010494 [cytoplasmic stress granule]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
GO:0048814 [regulation of dendrite morphogenesis]
GO:0060271 [cilium morphogenesis]
GO:0071598 [neuronal ribonucleoprotein granule]
GO:0072372 [primary cilium]
GO:0097546 [ciliary base]
Show all
 265 aa
30.5 kDa 		No 0
PQBP1-202
ENSP00000365747
ENST00000376563
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 265 aa
30.5 kDa 		No 0
PQBP1-203
ENSP00000365750
ENST00000376566
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 170 aa
18.8 kDa 		No 0
PQBP1-204
ENSP00000379985
ENST00000396763
O60828 [Direct mapping]
Polyglutamine-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016607 [nuclear speck]
GO:0031175 [neuron projection development]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043484 [regulation of RNA splicing]
Show all
 265 aa
30.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.